Project Grant R21EY038064
- Federal Project Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $132,837 to Boston Children's Hospital for a two-year project (May 1, 2026 – April 30, 2028) investigating SARM1 (Sterile Alpha and TIR Motif Containing 1) as a therapeutic target for autosomal dominant optic atrophy (ADOA) and Leber hereditary optic neuropathy (LHON). The project delivers foundational research and translational science aimed at understanding disease...
- Federal Grant Award Summary Boston Children's Hospital received a $136,512 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) effective July 1, 2025, through June 30, 2027. The award supports research investigating how intrinsically photosensitive retinal ganglion cells (ipRGCs) transform light information in melanopsin pathways to regulate physiological and behavioral responses. The research employs advanced imaging techniques to measure...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $545,948 to The Schepens Eye Research Institute, Inc. under the Vision Research program (CFDA 93.867) beginning April 1, 2026, through March 31, 2030. This Project Grant funds basic and translational research to understand the role of reactive astrocytes in glaucoma pathogenesis. The research deliverables will include scientific findings on how astrocytes in the optic nerve head respond to ocular hypertension,...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded a $534,000 Project Grant to Boston Children's Hospital effective April 1, 2026, through March 31, 2028, under the Vision Research program (CFDA 93.867). This two-year planning grant supports the development of a systematic pathway to identify pediatric patients eligible for antisense oligonucleotide (ASO) treatment of inherited retinal disorders (IRDs) caused by cryptic splicing defects. The research team will conduct a...
- Federal Project Grant Award Summary Award Details: The National Eye Institute (NEI), operating under the Vision Research program (CFDA 93.867), awarded $802,355 to Harvard Medical School (President and Fellows of Harvard College) on May 1, 2026, with a completion date of February 28, 2030. The award funds a research project titled "Experience-Driven Astrocytic Glucocorticoid Signaling as a Regulator of Visual Plasticity," to be conducted at the awardee's Boston, Massachusetts location....
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded Trustees of Boston University a $966,655 Project Grant on August 1, 2025, with a completion date of February 28, 2030. The award funds research testing a dynamic spatiotemporal normalization framework for human vision—a computational model designed to unify how the visual system processes information across both space and time. The project addresses a critical gap in vision...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $173,016 to the Whitehead Institute for Biomedical Research under the Vision Research program (CFDA 93.867) for a project grant effective August 1, 2025, through July 31, 2027. This award supports systematic identification and mechanistic characterization of novel oxidative protective genes to prevent retinal pigment epithelium (RPE) degeneration in age-related macular degeneration (AMD). The research involves...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $435,052 Vision Research (CFDA 93.867) Project Grant to the University of Massachusetts Boston for the period July 1, 2025 through June 30, 2029. This research project will investigate the molecular and genetic mechanisms that control photoreceptor subtype specification for color vision in the fruit fly (Drosophila melanogaster) retina as a model system. The research will identify conserved transcription factors and...
- Federal Project Grant Award Summary Award Overview Massachusetts General Hospital received a $453,750 Vision Research (CFDA 93.867) Project Grant from the National Eye Institute, effective September 1, 2025, through August 31, 2027. The award supports fundamental neuroscience research aimed at characterizing the cellular architecture and genetic organization of the lateral geniculate nucleus (LGN), a critical visual processing center in the brain. Research Products and Services The project...
- Federal Grant Award Summary Oregon Health & Science University received a $264,435 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective May 1, 2026 through April 30, 2031. The award funds research to define the pathophysiology of microcephaly and chorioretinopathy (MCCRP), a rare autosomal recessive neurodevelopmental disorder characterized by abnormal retinal and brain vascular development. The research examines the role of the...
The National Eye Institute (NEI) awarded Boston Children's Hospital a $489,500 Project Grant under the Vision Research program (CFDA 93.867) for the period July 1, 2026 through June 30, 2028. The award supports research assessing neuronal and glial contributions to autosomal dominant optic atrophy (ADOA), a progressive neurodegenerative disorder characterized by retinal ganglion cell degeneration and vision loss. The project will deliver mechanistic insights into ADOA pathogenesis by using genetically modified mouse models with selective OPA1 gene knockdown in either retinal ganglion cells or oligodendrocytes to quantify the relative contributions of neuronal versus glial mitochondrial dysfunction to optic nerve myelin loss, axon degeneration, and visual deficits. The deliverables include quantitative analyses of optic nerve myelin structure, axon integrity, retinal ganglion cell survival, and visual evoked potentials across cell-type-specific OPA1 mutant models. Successful completion will establish which cell types require therapeutic intervention for ADOA treatment, directly addressing the current absence of effective therapies for this condition. The research will be conducted at Boston Children's Hospital in Boston, Massachusetts, leveraging the institution's established capabilities in neurodegenerative disease research and its collaborative relationship with Harvard Medical School.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $489.5k | 7/1/26 |