Project Grant R21EY037012
- This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, under the Vision Research (CFDA 93.867) program, provides $500,500 to support research on the role of retinal ganglion cells in shaping the identity and function of neurons in the superior colliculus visual processing region. The key objectives are to: 1) determine how retinal input influences the morphology and transcriptional profiles of genetically-defined neuron...
- This federal Project Grant award of $428,349 from the National Eye Institute's Vision Research program (CFDA 93.867) supports research into the mechanistic assessment of retinal ganglion cell genesis. The award, with a performance period from July 1, 2025 to March 31, 2030, aims to investigate the shared gene regulatory network and downstream targets of the key transcription factors Atoh7, Pou4f2, and Isl1 that are required for proper retinal ganglion cell development. The research will be...
- This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) supports research to understand the relationship between visual feature representation in the inferior temporal cortex and spatial representations in the medial temporal lobe of the primate brain. The $576,474 award to President and Fellows of Harvard College, operating as Harvard Medical School, will utilize innovative neuroimaging and analysis techniques to characterize how visual and spatial...
- This federal Project Grant award from the National Eye Institute (NEI), under the CFDA program "Vision Research", provides $132,597 to The Schepens Eye Research Institute, Inc. to investigate the role of neural activity in retinal ganglion cell (RGC) integration and functional connectivity to improve RGC replacement therapies for glaucoma. The research aims to 1) characterize retinal remodeling following RGC inactivation, and 2) determine if inhibiting host neural activity can...
- This Project Grant award for $679,159 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research on in vivo epigenetic reprogramming of retinal ganglion cells (RGCs) in aging mice with glaucoma. The research aims to identify new therapeutic targets for glaucoma that can protect and rejuvenate RGCs, which are specifically targeted and damaged in this disease leading to vision loss. The 4-year project, awarded to The Schepens Eye...
- This Project Grant award of $568,122.00, provided by the National Eye Institute (CFDA 93.867 - Vision Research), supports research at Baylor College of Medicine to unequivocally confirm the contribution of the neurovascular unit to glaucoma pathogenesis and identify endothelial cell-specific ligands with potential for neuroprotective therapy. The research aims to globally map ligands binding to ocular hypertension and healthy retinal cells, systematically identifying ocular...
- This $146,922 project grant award from the National Eye Institute's Vision Research program (CFDA 93.867) supports research at The Johns Hopkins University to understand the chromatin architectural landscape of retinal development at the single-cell level. The project aims to identify how transcription factors manipulate genomic structure to control cell fate specification in the retina, a model system for studying neuronal development. Specifically, the research will use single-cell Hi-C and...
- This $473,750 Project Grant awarded by the National Eye Institute (CFDA 93.867 - Vision Research) supports a pilot study at Boston University to generate a first-ever, cell-type-specific, functional map of face processing areas in the primate brain using the common marmoset model. The researchers will leverage newly generated atlases of molecularly-defined cell types in the marmoset brain to survey and relate the genetic identity of different face areas and individual face cells to their...
- This $192,900 federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) supports research at Albert Einstein College of Medicine to investigate how locomotion affects the flow of visual information between brain areas. The project will use high-density laminar probes to record population activity from multiple visual areas in mice under different locomotive contexts. The researchers will evaluate changes in inter-areal visual signal communication using...
- This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides funding to researchers at the University of California, San Francisco (UCSF) to study the neural mechanisms underlying visual processing and behavior after photoreceptor degeneration. The $237,588 award, spanning June 2025 through December 2027, will leverage the vertical optokinetic reflex (OKR) - a visual behavior that tracks global motion - to investigate how cone degeneration disrupts noise...
This Project Grant award, provided by the National Eye Institute (CFDA 93.867 - Vision Research), will support research at Massachusetts General Hospital (MGH) to analyze the spatial distribution of genetically-defined cell classes across the human lateral geniculate nucleus (LGN) using spatial transcriptomics. The $453,750 award, spanning September 1, 2025 to August 31, 2027, will enable MGH researchers to generate and analyze data sets from human autopsy tissue to better understand the diversity and organization of cell types within the LGN. This research aims to build upon recent findings suggesting a more complex architecture in the LGN than previously understood, and test hypotheses about the spatial layout of different LGN neuron subclasses. The data generated through this project will contribute to a more nuanced understanding of the structure and function of the human visual system.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/29/25 | ||
| Not listed | $453.8k | 8/14/25 |