Project Grant R21EY036537
Award Date
9/30/24
Completion Date
8/31/26
Dollars Obligated
$184K
Federal Agency
National Eye Institute
Federal Grant Program
93.867
Assistance Type
Project Grant
Place of Performance
Rochester, MI, USA
Similar Awards
The National Eye Institute (NEI), under the Department of Health and Human Services, awarded a $440,806 Project Grant (CFDA 93.867 - Vision Research) to The Research Foundation for the State University of New York (RF SUNY) to study the role of the molecular chaperone p58IPK in retinal neurons under diabetic conditions. The goal is to define the in vivo function of p58IPK in regulating protein and lipid homeostasis through the integrated stress response and lipid glycosylation pathways, and to...
The National Eye Institute (NEI) awarded a $131,281 Project Grant under the Vision Research program (CFDA 93.867) to Northwestern University to support research on the role of myeloid cell transendothelial migration in non-proliferative diabetic retinopathy. The research aims to determine whether and when blocking CCL2-driven myeloid cell infiltration can halt the progression of inflammation in the mouse retina, and whether blocking leukocyte-endothelial interactions early in the disease...
This federal Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) provides $144,362 to support research on the role of hyperglycemia and hyperinsulinemia in the breakdown of the blood-retinal barrier in diabetic retinopathy. The project aims to identify the spatial localization and functions of claudins, key tight junction proteins, in the retinal pigment epithelium (RPE) and test the hypothesis that regulation of RPE claudins by hyperglycemic...
This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $939,708 to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the role of histone deacetylases HDAC6 and SIRT1 in the development of diabetic retinopathy, a leading cause of blindness. The research aims to study how an imbalance between HDAC6 and SIRT1 contributes to retinal vascular senescence and diabetic microangiopathy, as well...
The National Eye Institute (NEI) awarded a $624,230 Project Grant under the Vision Research program (CFDA 93.867) to the University of California, Los Angeles (UCLA) for the period of May 1, 2025 to April 30, 2029. The grant supports research to investigate the physiology of retinal degeneration and how the retina maintains visual processing as photoreceptors are lost. Key objectives include documenting changes in rod function and connectivity to bipolar cells, and exploring the plasticity and...
The National Eye Institute (NEI) awarded a $603,488 Project Grant (CFDA 93.867 - Vision Research) to Versiti Wisconsin, Inc. to conduct research on the role of the protein Rap1B in regulating inflammation and homeostasis in retinal endothelial cells. The project aims to: Assess how Rap1B influences the organization and signaling of lipid rafts containing the VEGF receptor VEGFR2, which is critical for maintaining endothelial health. Examine how Rap1B controls the balance between VEGFR2 and...
This $439,137 Project Grant was awarded by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) to the University of Arkansas for Medical Sciences (UAMS) to support research aimed at identifying cellular mechanisms and therapeutic targets for retinal neurovascular diseases such as diabetic retinopathy, retinal artery/vein occlusion, and traumatic optic neuropathy. The research will focus on studying the process of "efferocytosis", which refers to the...
The National Eye Institute (NEI), part of the National Institutes of Health, awarded a $331,131 Project Grant under the Vision Research program (CFDA 93.867) to Physical Sciences Inc. (PSI) to develop and validate a high-resolution retinal imaging system with light flicker capabilities. This system aims to enable objective characterization of the photoreceptor response to light and quantify differences between normal and diseased eyes, particularly for patients with diabetic retinopathy. PSI,...
This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $248,999 to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to investigate how neuronal activity and neurotransmitter signaling influence retinal angiogenesis and blood-retina barrier (BRB) maturation. The research aims to elucidate the mechanisms by which synaptic glutamate release regulates deep plexus angiogenesis and BRB integrity, including the role of...
This Project Grant award, funded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867), supports a research project focused on understanding genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The total award amount is $385,000.00 over a 4-year period from August 1, 2025 to July 31, 2029. The project, led by researchers at Wayne State University, aims to compare the transcriptional, cellular, and functional...