This federal Project Grant award, provided by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), funds research on the role of hyperglycemia and hyperinsulinemia in the breakdown of the blood-retinal barrier in diabetic retinopathy. The $144,362 award, effective September 1, 2024 through February 28, 2027, will support investigations to identify the spatial localization and functions of claudins, tight junction proteins that play a key role in the outer...
The National Eye Institute (NEI), under its Vision Research grant program (CFDA 93.867), awarded a $190,538 Project Grant (R21EY037036) to the University of Nebraska Medical Center (UNMC) to develop and characterize the use of an improved fluorescent glutamate sensor, iGluSnFR3, for measuring synaptic glutamate release from retinal rod photoreceptor cells. The project aims to provide an optical approach for studying glutamate release from rods, which is challenging to measure using traditional...
The National Eye Institute (NEI) awarded a Project Grant (CFDA 93.867 Vision Research) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University in the amount of $242,310.00 on Jun 1, 2024. The grant will fund a research project titled "Characterizing the Role of Mitochondrial DNA Mutations on Retinal Degeneration" through Jan 31, 2027. The project aims to utilize novel pre-clinical models to investigate how impaired mitochondrial function due to...
The National Eye Institute (NEI) awarded a $184,117 Project Grant (CFDA 93.867 - Vision Research) to Oakland University to investigate the role of G-protein coupled receptors GPR31 and GPR39 in the pathogenesis of diabetic retinopathy. The research aims to determine the affinities and substrate specificities of these receptors for the 12/15-lipoxygenase metabolites 12-HETE and 15-HETE, and to examine the effects of GPR31 and GPR39 gain-or-loss-of-function on retinal endothelial cells and...
The National Eye Institute (NEI) has awarded a Project Grant (CFDA 93.867 Vision Research) totaling $421,600.00 to Tufts Medical Center in Boston, MA. The 5-year grant, awarded on August 1, 2024, aims to delineate the regulatory mechanisms that facilitate neovascular growth and regression in proliferative retinopathies, which are leading causes of blindness. The key research objectives are to: 1) Determine the role of chemokine signaling in facilitating non-resident immune cell recruitment and...
This $220,463 Project Grant awarded by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) aims to investigate atypical pathological signaling as a target to regulate retinal vasculopathies over a two-year period from June 2024 to May 2026. The grant will fund research using mouse models and human retinal cell cultures to define the role of the atypical p38 signaling pathway in propagating vascular inflammation and abnormal blood vessel growth in retinal diseases....
The National Eye Institute (NEI) awarded a $595,302 Project Grant (CFDA 93.867 Vision Research) to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, to conduct research on how glucose transport and metabolism support the health and function of the retina and photoreceptors. The 5-year project, running from April 1, 2025 to March 31, 2030, will investigate the roles of the retinal pigment epithelium (RPE) and rod photoreceptors in utilizing glucose, as well as how...
The National Eye Institute (NEI) awarded a $228,718 Project Grant (CFDA 93.867 - Vision Research) to the University of California, Los Angeles (UCLA) to characterize the visual properties and transcriptomic signatures of excitatory neurons in the primary visual cortex (V1) of mice. The project aims to establish correlations between cell type and visual function in V1 by combining in-vivo two-photon calcium imaging to study neuronal receptive fields with expansion-assisted iterative FISH to...
The National Eye Institute (NEI) awarded a $360,897 Project Grant (CFDA 93.867 - Vision Research) to Human Cell Co, a for-profit biotechnology research and development company located in Naperville, Illinois. The grant funding will support a Phase 1 study to determine whether combining topical administration of a novel nerve growth factor (NGF) mutein, HC201, with oral nicotinamide (NAM) supplementation can more effectively improve retinal ganglion cell (RGC) function compared to either...
The National Eye Institute (NEI) awarded The Ohio State University a 5-year, $513,371 Project Grant under the Vision Research program (CFDA 93.867) to conduct a comprehensive investigation of the role of the cGAS-STING pathway in oxidative retinal damage. The research aims to 1) elucidate the molecular mechanisms governing the escape of self-DNA into the cytosol during oxidative stress, 2) define the activation of cGAS-driven effector pathways in mouse retinal and RPE tissue under acute and...