This Project Grant award, funded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867), supports research focused on identifying cellular mechanisms and therapeutic targets for retinopathies caused by ischemia or trauma, including diabetic retinopathy, retinal artery or vein occlusion, and traumatic optic neuropathy. The central hypothesis is that upregulation of the enzyme histone deacetylase 3 (HDAC3) in myeloid cells after retinal injury increases...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), will support research to investigate the role of interleukin-6 (IL-6) signaling in the development of diabetic retinopathy. The research aims to: Determine how disruption of the IL-6 "cis-trans balance" in Muller glial cells affects vascular endothelial growth factor (VEGF) expression, leading to oxidative stress and breakdown of the inner blood-retinal...
This $2,305,702 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) will support an integrative multi-omics study to discover molecular pathways associated with diabetic retinopathy. The primary awardee, Vanderbilt University Medical Center, will quantify differential transcript and metabolite abundance between participants with type 2 diabetes with and without diabetic retinopathy in the Cameron County Hispanic Cohort and the Hispanic...
The National Eye Institute (NEI) awarded a $144,362 Project Grant under the Vision Research program (CFDA 93.867) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The grant supports research to identify the role of hyperglycemia and hyperinsulinemia in the breakdown of the blood-retinal barrier, which is a key event in the development of diabetic retinopathy, a leading cause of preventable blindness. The research aims to understand the molecular mechanisms...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), will investigate the potential impact of chronic HIV infection and/or anti-HIV drugs on the development and progression of ischemic retinopathies. The total funding amount is $231,000.00, with a project period from February 1, 2025 to January 31, 2027. The award recipient is the Augusta University Research Institute, Inc., doing business as Georgia Health Sciences, a non-profit...
The National Eye Institute (NEI) has awarded a $184,117 Project Grant under the Vision Research program (CFDA 93.867) to Oakland University, a public research university in Rochester, Michigan. The grant, awarded for the period of September 30, 2024 to August 31, 2026, will support research to determine the role of G-coupled protein receptors GPR31 and GPR39 in the pathogenesis of diabetic retinopathy. The project aims to investigate the affinities and substrate specificities of GPR31 and...
The National Eye Institute (NEI) awarded a $131,281 Project Grant under the Vision Research program (CFDA 93.867) to Northwestern University to investigate the role of myeloid cell transendothelial migration in non-proliferative diabetic retinopathy. The project aims to determine whether and when blocking CCL2-driven myeloid cell infiltration can halt disease progression, and if blocking leukocyte-endothelial interactions early in the disease course can reduce diabetic retinopathy progression....
The National Eye Institute (NEI) awarded a $2,270,408 Project Grant (CFDA 93.867 - Vision Research) to Wake Forest University Health Sciences to develop and evaluate RXR-based therapies for treating diabetic retinopathy. The overarching goal is to determine if intravitreal delivery of RXR agonist microparticles (UAB126-MP and UAB30-MP) can activate RXR signaling to normalize retinal lipid metabolism and reduce inflammation, thereby preventing and reversing diabetic retinopathy. The project...
This $403,750 Project Grant from the National Eye Institute of the Department of Health and Human Services will fund research into the regulation of retinal microvascular stiffness by the matricellular protein CCN1 and its implications for ischemic retinopathy. The awardee, the Research Foundation for the State University of New York on behalf of SUNY Downstate Health Sciences University, will investigate the effects of CCN1 on the mechanical properties of retinal microvascular endothelial cells...
This $241,500 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) aims to evaluate the impact of patient, neighborhood, and community characteristics on screening and monitoring adherence for diabetic retinopathy (DR) among Medicare beneficiaries with diabetes. The research will use Medicare data linked with the Area Deprivation Index and local healthcare environment measures to identify factors associated with adherence to recommended...