This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $469,854 in funding to Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the role of histone deacetylases in retinal vascular senescence and diabetic retinopathy. The key research objectives are to: 1) Investigate the contribution of HDAC6 to retinal vascular senescence, diabetic microangiopathy, and diabetic retinopathy; and 2) Investigate the...
The U.S. National Eye Institute (NEI) awarded a $184,117 Project Grant (CFDA 93.867 - Vision Research) to Oakland University to determine the role of G-coupled protein receptors GPR31 and GPR39 in the pathogenesis of diabetic retinopathy. The project aims to investigate the affinities and substrate specificities of GPR31 and GPR39 for 12- and 15-HETE metabolites in retinal endothelial cells and Müller cells under normal and hyperglycemic conditions. It will also examine the effects of GPR31 or...
This Project Grant award of $400,000.00 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research to investigate the ontology and function of retinal perivascular macrophages during neuroinflammation. The research aims to determine the origin and longevity of these macrophages, as well as their role in experimental autoimmune uveitis and diabetic retinopathy. This work will advance the understanding of the blood-retina barrier and its disruption in...
This $440,806 Project Grant award from the National Eye Institute (NEI) Vision Research program (CFDA 93.867) aims to define the role of the molecular chaperone P58IPK in regulating protein and lipid homeostasis in retinal neurons under diabetic conditions. The research seeks to advance understanding of the mechanisms by which P58IPK deficiency leads to neurodegeneration and develop new treatments for diabetic retinopathy, a leading cause of blindness. The award recipient, The Research...
This federal Project Grant award from the National Eye Institute (NEI), under CFDA program 93.867 "Vision Research", provides $2,305,702 to Vanderbilt University Medical Center to conduct an integrative multi-omics study to discover molecular pathways associated with diabetic retinopathy. The study aims to quantify differential transcript and metabolite abundance between participants with type 2 diabetes with and without diabetic retinopathy, and replicate the findings in an...
The National Eye Institute (NEI) awarded a $131,281 Project Grant under the Vision Research program (CFDA 93.867) to Northwestern University to support research on the role of myeloid cell transendothelial migration in non-proliferative diabetic retinopathy. The research aims to determine whether and when blocking CCL2-driven myeloid cell infiltration can halt the progression of inflammation in the mouse retina, and whether blocking leukocyte-endothelial interactions early in the disease...
This $670,496 Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research to investigate the paradoxical role of anti-VEGF therapy in subretinal fibrosis (SRF) associated with neovascular age-related macular degeneration (NAMD). The project aims to elucidate the mechanisms by which anti-VEGF therapy at different disease stages impacts SRF, and to develop novel dual anti-angiogenesis and anti-fibrosis therapies. The...
This $403,750 Project Grant from the National Eye Institute of the Department of Health and Human Services will fund research into the regulation of retinal microvascular stiffness by the matricellular protein CCN1 and its implications for ischemic retinopathy. The awardee, the Research Foundation for the State University of New York on behalf of SUNY Downstate Health Sciences University, will investigate the effects of CCN1 on the mechanical properties of retinal microvascular endothelial cells...
This $606,034 Project Grant awarded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) supports research to investigate the role of Müller glia cells in the acute and chronic inflammatory response in the retina under various stress, injury, and disease conditions. The research aims to provide a deeper understanding of the molecular and cellular mechanisms that maintain retinal homeostasis and how those mechanisms are disrupted during acute and...
This $421,600 Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) will support research at Tufts Medical Center in Boston, MA to investigate the regulatory mechanisms governing retinal neovascularization. The research aims to delineate the role of chemokine signaling in recruiting peripheral immune cells to facilitate pathological vascular growth, as well as the role of microglial complement receptors in regulating neovessel regression. The project will utilize...