Project Grant R01EY036588

Award Date 9/30/24
Completion Date 8/31/29
Dollars Obligated $603K
Federal Grant Program
93.867
Assistance Type
Project Grant
Place of Performance
Milwaukee, WI 53226, USA
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The National Eye Institute (NEI) awarded a $131,281 Project Grant under the Vision Research program (CFDA 93.867) to Northwestern University to support research on the role of myeloid cell transendothelial migration in non-proliferative diabetic retinopathy. The research aims to determine whether and when blocking CCL2-driven myeloid cell infiltration can halt the progression of inflammation in the mouse retina, and whether blocking leukocyte-endothelial interactions early in the disease...
The U.S. National Eye Institute (NEI) awarded a $184,117 Project Grant (CFDA 93.867 - Vision Research) to Oakland University to determine the role of G-coupled protein receptors GPR31 and GPR39 in the pathogenesis of diabetic retinopathy. The project aims to investigate the affinities and substrate specificities of GPR31 and GPR39 for 12- and 15-HETE metabolites in retinal endothelial cells and Müller cells under normal and hyperglycemic conditions. It will also examine the effects of GPR31 or...
This federal Project Grant award of $400,000.00 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research at Northwestern University to investigate the ontological origin, function, and role of retinal perivascular macrophages in the blood-retina barrier during diabetic retinopathy and experimental autoimmune uveitis. The research aims to determine the developmental origin of these macrophages, assess their necessity for initiating autoimmune...
This $421,600 Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) will support research at Tufts Medical Center in Boston, MA to investigate the regulatory mechanisms governing retinal neovascularization. The research aims to delineate the role of chemokine signaling in recruiting peripheral immune cells to facilitate pathological vascular growth, as well as the role of microglial complement receptors in regulating neovessel regression. The project will utilize...
This Project Grant award, totaling $2,305,702.00, was provided by the National Eye Institute (NEI) under the Vision Research (CFDA 93.867) federal grant program. The award supports a multi-omics study to discover molecular pathways associated with diabetic retinopathy, a leading cause of blindness that disproportionately affects Hispanic/Latino populations. Key project goals include quantifying differential transcript and metabolite abundance between participants with and without diabetic...
The National Eye Institute (NEI), under the Department of Health and Human Services, has awarded a $568,122 Project Grant (CFDA 93.867 - Vision Research) to Baylor College of Medicine. The grant, effective from July 1, 2025, through March 31, 2030, aims to confirm the contribution of the neurovascular unit (NVU) to the pathogenesis of glaucoma and identify endothelial cell-specific ligands with potential for neuroprotective therapy. The key objectives of this project are to: 1) globally map...
This federal Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) provides $144,362 to support research on the role of hyperglycemia and hyperinsulinemia in the breakdown of the blood-retinal barrier in diabetic retinopathy. The project aims to identify the spatial localization and functions of claudins, key tight junction proteins, in the retinal pigment epithelium (RPE) and test the hypothesis that regulation of RPE claudins by hyperglycemic...
The National Eye Institute (NEI), part of the National Institutes of Health, awarded a $331,131 Project Grant under the Vision Research program (CFDA 93.867) to Physical Sciences Inc. (PSI) to develop and validate a high-resolution retinal imaging system with light flicker capabilities. This system aims to enable objective characterization of the photoreceptor response to light and quantify differences between normal and diseased eyes, particularly for patients with diabetic retinopathy. PSI,...
This $439,137 Project Grant was awarded by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) to the University of Arkansas for Medical Sciences (UAMS) to support research aimed at identifying cellular mechanisms and therapeutic targets for retinal neurovascular diseases such as diabetic retinopathy, retinal artery/vein occlusion, and traumatic optic neuropathy. The research will focus on studying the process of "efferocytosis", which refers to the...
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The National Eye Institute (NEI) awarded a $603,488 Project Grant (CFDA 93.867 - Vision Research) to Versiti Wisconsin, Inc. to conduct research on the role of the protein Rap1B in regulating inflammation and homeostasis in retinal endothelial cells. The project aims to:

  1. Assess how Rap1B influences the organization and signaling of lipid rafts containing the VEGF receptor VEGFR2, which is critical for maintaining endothelial health.
  2. Examine how Rap1B controls the balance between VEGFR2 and inflammatory TNF receptor TNFR1 signaling in retinal endothelial cells.
  3. Establish the impact of endothelial Rap1B on leukocyte-dependent vascular changes in diabetic retinopathy and retinopathy of prematurity models.

The project involves sub-awards to the Medical College of Wisconsin and the University of Alabama at Birmingham to provide specialized in vitro and in vivo research support. The findings aim to provide insights into the mechanisms governing the balance of endothelial responses to both pro-angiogenic and pro-inflammatory stimuli, which is critical for developing improved treatments for retinal ischemic diseases.

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