Project Grant R21ES023032

The National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health Federal Grant Program (CFDA 93.113), awarded a $2,472,661 Project Grant to the Texas A&M University System Health Science Center (TAMU HSC) to investigate the effects of phthalate exposure on epigenetic regulation of metabolic pathways and the development of metabolic diseases. The 4-year project, commencing on September 15, 2025, aims to elucidate the mechanisms by which phthalates, a group of...

The National Institutes of Health's National Center for Advancing Translational Sciences (NCATS) awarded a $145,636 project grant (CFDA 93.350) to Beth Israel Deaconess Medical Center, Inc. (Bidmc) to evaluate the relationship between thyroid hormone levels and brown adipose tissue activity, transcriptome, and cellular composition in adult humans. The study aims to better understand the interaction between the thyroid axis and brown adipose tissue in the process of thermogenesis and energy...

This Project Grant award of $307,508 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop a novel bioengineered brown adipocyte (fat cell) transplant as a potential new therapy for treating obesity and associated metabolic disorders. The award will fund research by United Biotherapeutics LLC to further develop a safer and more efficient adeno-associated...

This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health federal grant program (CFDA 93.113), provides $124,808.00 in funding to the University of Texas at Austin to investigate how exposure to environmental endocrine-disrupting chemicals (EDCs) impacts cognitive and food reward processes in the brain, with a focus on dopamine pathways. The research aims to explore the potential role of EDCs in the co-morbidity of obesity and...

The University of Pennsylvania was awarded a $1,418,750 Project Grant from the National Institutes of Health (NIH) Trans-NIH Research Support Program (CFDA 93.310) to conduct research on "Optogenetic Engineering of Thermogenic Adipose Tissue as a Novel Cell Therapy for Obesity." The goal of this project is to develop new treatments to increase energy expenditure and combat the public health challenge of obesity, which affects over 40% of the U.S. population. The research aims to...

The University of Washington was awarded a $805,464 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to conduct research on the genetic and environmental contributions to obesity pathogenesis. The award, effective August 1, 2025 through April 30, 2030, will focus on using rodent models and epidemiologic/twin study approaches to: 1) test genetic risk factors for hypothalamic gliosis, and 2) test environmental risk factors for obesity and...

This $756,318 federal Project Grant was awarded on June 3, 2025 by the National Institute of Environmental Health Sciences (NIEHS), a division of the U.S. National Institutes of Health (CFDA 93.113 Environmental Health). The grant supports research at Wayne State University to investigate how polyethoxylated surfactants, a class of emerging environmental contaminants, impact metabolic health and the development of obesity. The research will use zebrafish models to comprehensively assess the role...

This $221,252 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to develop a drug delivery system that modulates adipose (fat) tissue function to enhance metabolism and promote weight management. The key products and services to be delivered under this 12-month grant include: Establishing a correlation between the physicochemical properties of engineered hybrid...

This $1,280,753 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) supports research on the role of hypothalamic SH2B1 neurocircuits and SH2B1 signal transduction pathways in obesity and metabolic disease. The research, conducted by the Regents of the University of Michigan, aims to identify SH2B1-expressing neurons in the paraventricular hypothalamus (PVH) that control...

This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health federal grant program (CFDA 93.113), supports research into how exposure to polychlorinated biphenyls (PCBs) and high-fat diets impact the development of metabolic dysfunction-associated steatotic liver disease (MASLD). The $3,051,769 award to the University of Louisville aims to determine how environmental exposures and diet modify RNA modifications, specifically...