Project Grant R03TR004808
Award Date
8/15/24
Completion Date
7/31/26
Dollars Obligated
$146K
Federal Agency
National Center for Advancing Translational Sciences
Federal Grant Program
93.350
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
Similar Awards
This Project Grant award of $604,853 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will fund research at Rockefeller University to elucidate the genetic determinants of human brown adipose tissue (BAT) function. The goal is to develop a better understanding of how BAT, which can protect against obesity and associated metabolic diseases, is regulated in humans. The research will leverage...
The federal Project Grant award R01DK140455 in the amount of $333,000.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports a randomized, three-arm, double-blind, controlled, escalating dose parallel pilot study to evaluate the safety and efficacy of once-daily versus twice-daily administration of levothyroxine (LT4) and liothyronine (LT3)...
This $107,250 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support research to investigate the role of the nuclear receptor NR2F2 in driving the development of beige adipose tissue to protect against obesity. The research aims to elucidate how early-life exposure to high omega-6 fatty acids impacts adipose stem cell fate and...
This $578,060 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to study a potential new enhancer region that activates the UCP1 gene, which is critical for thermogenesis and energy expenditure. The research will examine how this enhancer functions to increase UCP1 transcription, as well as assess its impact on thermogenesis, adiposity, and...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports a research project titled "Redefining and Improving Hypothyroidism Care Using Real-World Data." The $172,003 award aims to determine the association between cumulative thyroid-stimulating hormone (TSH) control and cardiovascular outcomes in patients with...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $570,268 to investigate the regulation of adipose tissue remodeling by the CCNC-Mediator complex. The research, conducted by the Albert Einstein College of Medicine, aims to study the cell-autonomous mechanisms and metabolic functions of enhanced white adipose tissue browning upon...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $152,454 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Dana-Farber Cancer Institute, Inc. (DFCI) in Boston, MA. The grant, titled "The Mechanistic Study on Irisin-Mediated Immune Response and Its Role in Adipose Tissue Dynamics," aims to conduct research on the role of the irisin hormone in regulating immune response and adipose...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $245,123 to support research on the role of vascular sympathetic neurons in brown adipose tissue and their impact on systemic metabolism. The project, led by The Trustees of Columbia University in the City of New York, aims to use novel genetic and chemogenetic tools, advanced...
This Project Grant award of $361,250.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports a Phase 2 clinical trial to evaluate the use of the drug atomoxetine for treating obesity caused by melanocortin-4 receptor (MC4R) deficiency. The trial will be conducted by the Icahn School of Medicine at Mount Sinai and will assess the safety and efficacy of atomoxetine...
This federal Project Grant award, valued at $163,344.00, was issued by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The research aims to determine the role of thyroid hormones, specifically the enzyme type 3 deiodinase (DIO3), in driving sex-specific outcomes in cardiovascular health. The study will investigate whether DIO3 expression post-myocardial infarction differs between sexes, potentially contributing to higher...