Project Grant R01ES036210
- This $171,064 project grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health federal grant program (CFDA 93.113), supports research to investigate how polychlorinated biphenyls (PCBs) affect adipocyte-macrophage crosstalk and influence the development of metabolic disorders. The research, to be conducted at the University of Iowa from January 1, 2025 to June 30, 2027, aims to determine how PCBs alter adipocyte-macrophage interactions...
- The federal Project Grant award R01ES036983 for $495,980.00 was provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program. The grant supports research to investigate the impact of polychlorinated biphenyls (PCBs) exposure on the development of depression in adolescent mouse models. The research aims to understand the mechanistic link between PCB exposure, gut microbiome changes, blood-brain barrier...
- This $794,841 Project Grant awarded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health federal grant program (CFDA 93.113) supports research investigating the impacts of early-life triclosan exposure through breastfeeding on the development of metabolic dysfunction-associated steatotic liver disease (MASLD), including adult and pediatric steatohepatitis (MASH), in mice. The research aims to determine how triclosan, a common antimicrobial found in...
- This $478,503 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113) supports research to investigate the impact of prenatal exposure to per- and polyfluoroalkyl substances (PFAS) on the development of non-alcoholic fatty liver disease (NAFLD) in children. The award will leverage the existing GUSTO mother-child cohort in Singapore to conduct comprehensive assessments, including proton magnetic resonance...
- This $418,702 federal Project Grant awarded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113) will support research at Baylor University to investigate the impact of altered biotransformation pathways on the ability of Gulf killifish to adapt to legacy pollutants like polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs). The project will examine how a deletion in the aryl hydrocarbon receptor (AhR)...
- This $431,750.00 federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113) supports a two-year study at the University of Louisville to assess the environmental and health impacts of an industrial accident in Calvert City, Kentucky. The study aims to establish air quality monitoring sites, conduct wastewater surveillance, and perform quarterly biological sampling to comprehensively evaluate exposure...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $705,279 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to Trustees of Boston University, doing business as Boston University Medical Campus, to investigate the mechanisms by which environmental pollutants impact the cardiovascular system. The 4-year project, starting January 1, 2025, will use a multidisciplinary approach including physiological studies, cellular imaging, RNA-sequencing, and mouse models to...
- The National Institute of Environmental Health Sciences (NIEHS) awarded Wayne State University a 3-year, $1,644,161 Project Grant under the Environmental Health program (CFDA 93.113) to study the effects of per- and polyfluoroalkyl substances (PFAS) on atherosclerosis and cholesterol metabolism. The project aims to determine if PFAS mixtures accelerate atherosclerosis in a mouse model, assess how PFAS disrupts bile acid reuptake and leads to increased cholesterol levels, and evaluate the...
- The University of Massachusetts Lowell received a $157,437 Project Grant from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health federal grant program (CFDA 93.113), to study the urinary, biliary, and fecal excretion of per- and polyfluoroalkyl substances (PFAS) and the impact of dietary fiber. The project aims to investigate the extent of enterohepatic recirculation of PFAS, which contributes to their long half-lives and increased risk of adverse...
- This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health Federal Grant Program (CFDA 93.113), will support research at Brown University to investigate the impact of prenatal exposure to per- and polyfluoroalkyl substances (PFAS) on adult cardiometabolic disease. The $656,250 award, with a performance period from August 6, 2025 to May 31, 2029, will enable researchers to conduct an unprecedented assessment of 44 individual PFAS,...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health federal grant program (CFDA 93.113), supports research into how exposure to polychlorinated biphenyls (PCBs) and high-fat diets impact the development of metabolic dysfunction-associated steatotic liver disease (MASLD). The $3,051,769 award to the University of Louisville aims to determine how environmental exposures and diet modify RNA modifications, specifically N6-methyladenosine (m6A), to regulate apolipoprotein homeostasis and contribute to MASLD progression. The research will use a variety of sequencing techniques to analyze m6A marks on transcripts like APOB that are critical for hepatic lipid accumulation. By addressing the knowledge gap on how diet, pollutants, and sex influence the epitranscriptome in MASLD, this project seeks to enhance understanding of the underlying mechanisms linking environmental exposures and metabolic diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.1m | 9/10/25 |