Project Grant R01DK144233
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $176,500.00 to the University of Washington to investigate the links between hypothalamic microglia activation and perineuronal net (PNN) loss in the arcuate nucleus, and how these changes contribute to the pathogenesis of diet-induced obesity and glucose regulation. The...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $136,449 to The Regents of the University of California, doing business as the University of California, Berkeley, to evaluate the role of human obesity genes in specific neuronal populations using a CRISPR-based approach. The research aims to determine how genetic variation...
- This $695,295 federal Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), which administers the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant was awarded on March 15, 2025 to the Research Foundation for the State University of New York (RF SUNY) to support a research project titled "Developmental Trajectories of Reinforcer Pathology and Childhood Obesity". The project aims to...
- This $1,280,753 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) supports research on the role of hypothalamic SH2B1 neurocircuits and SH2B1 signal transduction pathways in obesity and metabolic disease. The research, conducted by the Regents of the University of Michigan, aims to identify SH2B1-expressing neurons in the paraventricular hypothalamus (PVH) that control...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a component of the National Institutes of Health, awarded a $789,350 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Pennsylvania State University (Penn State) to investigate biological mechanisms of obesity in a high-risk pediatric cohort with confirmed maltreatment. The project aims to elucidate the impact of child maltreatment on obesity through...
- This $2,559,138 Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to define the mechanisms regulating adipose (fat) tissue metabolic memory and its role in rebound weight gain following obesity treatment. The project, led by researchers at the University of Pennsylvania, aims to: 1) determine the role of LYVE1+ macrophages in...
- The University of Oklahoma Health Sciences Center (OUHSC) received a $107,250 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant funds a research project titled "NR2F2 Pioneers Neonatal Beige Adipogenesis to Protect Against Later-Life Obesity". The project investigates how exposure to high omega-6 fatty acids during early...
- This federal Project Grant award for $732,261 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to identify central obesity genes and validate their function using in vitro and in vivo models. The project aims to leverage large-scale, multi-ethnic genomic and multi-omic data from nine longitudinal studies in the NHLBI Trans-Omics for Precision Medicine (TOPMed) program to pinpoint target genes that...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $773,112 Project Grant to Rockefeller University on September 5, 2025 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the mechanisms of transcriptional control in adipocyte formation and function through nuclear receptor coactivators. The research aims to provide a better understanding of dysregulation in energy storage...
- This $659,199 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to investigate a novel pathway by which hepatocyte-derived growth differentiation factor 15 (GDF15) can improve obesity-associated insulin resistance independent of changes in body weight. The research aims to characterize this GFRAL-independent mechanism and determine the stress signaling pathways...
The University of Washington was awarded a $805,464 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to conduct research on the genetic and environmental contributions to obesity pathogenesis. The award, effective August 1, 2025 through April 30, 2030, will focus on using rodent models and epidemiologic/twin study approaches to: 1) test genetic risk factors for hypothalamic gliosis, and 2) test environmental risk factors for obesity and hypothalamic gliosis to determine if environmental factors act independently of genetic makeup. The goal is to fill gaps in understanding the neurobiological underpinnings of genetic risk factors for common obesity and the mechanisms whereby genetic factors may magnify the risk of environmental exposures through effects on the brain.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $805.5k | 7/31/25 |