Project Grant R41DK142538
- This Project Grant award of $604,853 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will fund research at Rockefeller University to elucidate the genetic determinants of human brown adipose tissue (BAT) function. The goal is to develop a better understanding of how BAT, which can protect against obesity and associated metabolic diseases, is regulated in humans. The research will leverage...
- This $221,252 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to develop a drug delivery system that modulates adipose (fat) tissue function to enhance metabolism and promote weight management. The key products and services to be delivered under this 12-month grant include: Establishing a correlation between the physicochemical properties of engineered hybrid...
- This federal Project Grant award of $813,511 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at the Dana-Farber Cancer Institute, Inc. (DFCI) to investigate the structural basis and functional consequences of thermogenic mitochondrial respiratory complexes assembly in the context of obesity and type 2 diabetes. The research aims to...
- This federal Project Grant award of $350,000 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The objective is to validate the use of AVGN7 (rAAV6:SMAD7), a gene therapeutic, for treating obesity and type 2 diabetes mellitus (T2DM). The key products or services to be delivered include: (1) Demonstrating that AVGN7 can restore lean body mass and insulin...
- This federal Project Grant award for $849,788, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research), supports research to investigate the role of hyaluronan (HA) in promoting new beige adipocyte development, which could enhance adipose tissue thermogenesis and energy expenditure. The Beckman Research Institute of the City of Hope, a nonprofit medical research organization in California, is...
- This $3,065,252 federal Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The project aims to develop engineered metabolite-based nanoparticles for immunomodulation of macrophages to treat obesity, a critical health concern due to its links to metabolic diseases. The Terasaki Institute for Biomedical Innovation, a non-profit research...
- This $801,009 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports research by The Trustees of Columbia University in the City of New York to study the role of vascular sympathetic neurons in brown adipose tissue and their effects on systemic metabolism. The research aims to utilize newly developed mouse genetic and chemogenetic tools, improved imaging techniques, and in vivo assays to examine how distinct subpopulations of...
- The University of Pennsylvania was awarded a $1,418,750 Project Grant from the National Institutes of Health (NIH) Trans-NIH Research Support Program (CFDA 93.310) to conduct research on "Optogenetic Engineering of Thermogenic Adipose Tissue as a Novel Cell Therapy for Obesity." The goal of this project is to develop new treatments to increase energy expenditure and combat the public health challenge of obesity, which affects over 40% of the U.S. population. The research aims to...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $773,112 Project Grant to Rockefeller University on September 5, 2025 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the mechanisms of transcriptional control in adipocyte formation and function through nuclear receptor coactivators. The research aims to provide a better understanding of dysregulation in energy storage...
- This $2,559,138 Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to define the mechanisms regulating adipose (fat) tissue metabolic memory and its role in rebound weight gain following obesity treatment. The project, led by researchers at the University of Pennsylvania, aims to: 1) determine the role of LYVE1+ macrophages in...
This Project Grant award of $307,508 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop a novel bioengineered brown adipocyte (fat cell) transplant as a potential new therapy for treating obesity and associated metabolic disorders. The award will fund research by United Biotherapeutics LLC to further develop a safer and more efficient adeno-associated virus (AAV) vector system for generating "humble cells" - potent brown adipocyte-like cells derived from white preadipocytes using CRISPR/dCas9-SAM technology. This Phase I study will investigate the applicability of the AAV system to donor-derived, non-immortalized white preadipocytes, with the goal of generating new CRISPR-engineered, safer humble cells suitable for future clinical development as a novel therapeutic approach for obesity and metabolic disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $307.5k | 9/10/25 |