Project Grant DP2DK147746
- This $2,559,138 Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to define the mechanisms regulating adipose (fat) tissue metabolic memory and its role in rebound weight gain following obesity treatment. The project, led by researchers at the University of Pennsylvania, aims to: 1) determine the role of LYVE1+ macrophages in...
- This $1,169,317 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop a molecular toolbox for non-invasive methods to kill cells in situ via specific cell death pathways using safe, tunable temperature stimuli. The objective is to generate single protein constructs that can trigger apoptosis, necroptosis, or pyroptosis...
- This $221,252 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to develop a drug delivery system that modulates adipose (fat) tissue function to enhance metabolism and promote weight management. The key products and services to be delivered under this 12-month grant include: Establishing a correlation between the physicochemical properties of engineered hybrid...
- This federal Project Grant award of $121,875 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the developmental origins and cellular composition of dermal adipose tissue, which plays a significant role in whole-body metabolism. The research aims to elucidate how a specific transcription factor, BCL11B, modulates the...
- This $2,060,811 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on the role of activin type II receptor signaling in muscle hypertrophy, obesity, and weight loss. The research aims to understand how blocking the activin type II receptor can preserve lean muscle mass while maximizing fat loss during obesity treatment,...
- This Project Grant award, totaling $601,499 and spanning from June 2025 to May 2030, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research focused on understanding how maternal obesity during pregnancy alters mitochondrial function in the offspring, which is linked to the later development of obesity and metabolic syndrome. Key objectives include:...
- This Project Grant award of $307,508 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop a novel bioengineered brown adipocyte (fat cell) transplant as a potential new therapy for treating obesity and associated metabolic disorders. The award will fund research by United Biotherapeutics LLC to further develop a safer and more efficient adeno-associated...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a component of the National Institutes of Health, awarded a $789,350 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Pennsylvania State University (Penn State) to investigate biological mechanisms of obesity in a high-risk pediatric cohort with confirmed maltreatment. The project aims to elucidate the impact of child maltreatment on obesity through...
- The University of Pennsylvania received a $446,875 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award will support research to develop deep learning tools that can predict patient risk, generate synthetic clinical biomarkers, and provide normative data from multimodal and longitudinal health data related to metabolic...
- The University of Washington was awarded a $805,464 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to conduct research on the genetic and environmental contributions to obesity pathogenesis. The award, effective August 1, 2025 through April 30, 2030, will focus on using rodent models and epidemiologic/twin study approaches to: 1) test genetic risk factors for hypothalamic gliosis, and 2) test environmental risk factors for obesity and...
The University of Pennsylvania was awarded a $1,418,750 Project Grant from the National Institutes of Health (NIH) Trans-NIH Research Support Program (CFDA 93.310) to conduct research on "Optogenetic Engineering of Thermogenic Adipose Tissue as a Novel Cell Therapy for Obesity." The goal of this project is to develop new treatments to increase energy expenditure and combat the public health challenge of obesity, which affects over 40% of the U.S. population. The research aims to explore the use of thermogenic adipose tissue, a specialized "furnace" that burns energy, as a potential cell therapy to complement existing weight loss treatments and enable long-term weight maintenance. This 3-year project, starting on September 11, 2025, will leverage the University of Pennsylvania's expertise in biomedical sciences and medical research to advance this innovative approach to addressing the growing obesity epidemic.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.4m | 9/11/25 |