Project Grant R21DE035879
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded $398,000 to The Forsyth Institute under the Oral Diseases and Disorders Research program (CFDA 93.121) on July 15, 2025, for a two-year project grant concluding July 14, 2027. The research initiative investigates the mechanistic interactions between three bacterial species—Fusobacterium nucleatum, Actinomyces odontolyticus, and Nanosynbacter lyticus (TM7)—and their collective role in...
- The National Institute of Dental and Craniofacial Research awarded the University of North Carolina at Chapel Hill $682,398 under the Oral Diseases and Disorders Research program (CFDA 93.121) on August 1, 2026. The recipient will develop a predictive algorithm to identify individuals at high risk of developing long COVID based on high-resolution phenotyping of the immunologic, microbial, proteomic, and metabolomic landscape of the oral cavity during and after SARS-CoV-2 infection. The project...
- The National Institute of Dental and Craniofacial Research awarded $310,274 to the University of North Carolina at Chapel Hill on August 28, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds a multidimensional phenotyping study characterizing the molecular, sensory, and psychosocial factors underlying comorbid temporomandibular disorder and migraine in adolescents. The project recruits 140 youth aged 10 to 17 years with TMD myalgia, stratified by the...
- Federal Grant Award Summary The University of North Carolina at Chapel Hill received a $310,295 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded on September 11, 2025, with a completion date of September 10, 2027. This research initiative aims to identify distinct subgroups of adolescents with chronic temporomandibular disorder (TMD) pain based on clinically relevant features...
- The National Institute of Dental and Craniofacial Research awarded the University of Alabama at Birmingham $666,812 under the Oral Diseases and Disorders Research program (CFDA 93.121) on July 14, 2026, for a multilevel retrospective cohort study examining the impacts of Medicaid dental benefits expansion on oral healthcare workforce composition and services delivery at federally qualified health centers. The research employs an event-study difference-in-differences design using Uniform Data...
- The National Institute of Dental and Craniofacial Research awarded the University of North Texas $142,235 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the relationship between tongue positioning and velopharyngeal insufficiency in individuals with velopharyngeal dysfunction secondary to cleft palate with or without cleft lip. The research addresses the persistent challenge that behavioral interventions to reduce hypernasality—a...
- The National Institute of Dental and Craniofacial Research awarded the University of Pittsburgh $683,474 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to unravel the molecular basis of tooth agenesis through large-scale genetic discovery and functional characterization. The project will conduct whole-exome and whole-genome sequencing in approximately 450 individuals from a well-characterized tooth agenesis dataset to identify rare variants and test...
- The National Institute of Dental and Craniofacial Research awarded the University of Pittsburgh $679,631 on February 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate treatment for peri-implantitis via local immunomodulation and the microbiome. The project develops microparticle-based drug delivery systems that provide local, sustained delivery of cytokines and chemokines to modulate the host immune response in peri-implantitis, an inflammatory...
- The National Institute of Dental and Craniofacial Research awarded the University of Southern California $481,739 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop three-dimensional organoid models representing the stepwise neoplastic evolution of head and neck squamous cell carcinoma. The recipient institution will create organoids directly from normal human oral tissues, patient-derived leukoplakia samples, and head and neck squamous cell...
- The National Institute of Dental and Craniofacial Research awarded the University of Massachusetts Lowell $100,676 on September 30, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop a three-dimensional in vitro human periodontal sulcus tissue model capable of reproducing healthy and disease states of gingivitis and periodontitis. The recipient will engineer a sustained tissue culture system that mimics key anatomical features of the gingival sulcus—including...
The National Institute of Dental and Craniofacial Research awarded the University of North Carolina at Chapel Hill $444,319 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct an in vivo, longitudinal study investigating microplastic exposure from clear aligner orthodontic therapy. The research will collect saliva and urine samples from 60 orthodontic patients before initiating comprehensive clear aligner treatment and at two subsequent timepoints during full-time aligner wear. The study aims to determine whether clear aligner therapy significantly alters microplastic exposure, dosage, and physiologic uptake in patients, testing the hypothesis that aligner treatment will increase oral microplastic dosage and salivary exposure, leading to systemic dissemination and quantifiable biological effects. The investigation responds to public health concerns surrounding the global clear aligner market (valued at $6.5 billion in 2024), which has treated over 19 million patients including 5 million adolescents. Aligners changed weekly during treatment release microplastics that patients ingest; prior in vitro studies employing simulated oral conditions have confirmed this release, creating an urgent need for human data to inform clinical treatment recommendations and safeguard patient health. Performance occurs in Chapel Hill, North Carolina. The award period runs through July 31, 2028. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $444.3k | 7/24/26 |