Project Grant R01DE035709
- The National Institute of Dental and Craniofacial Research awarded $310,274 to the University of North Carolina at Chapel Hill on August 28, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds a multidimensional phenotyping study characterizing the molecular, sensory, and psychosocial factors underlying comorbid temporomandibular disorder and migraine in adolescents. The project recruits 140 youth aged 10 to 17 years with TMD myalgia, stratified by the...
- The National Institute of Dental and Craniofacial Research, part of the National Institutes of Health under the Department of Health and Human Services, awarded The University of Chicago $328,000 on August 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop and validate a microsimulation model of oral health lifetime outcomes and resource use in older adults. The project, titled "Development and Validation of the U.S. Oral Health Microsimulation...
- The National Institute of Dental and Craniofacial Research awarded the University of North Carolina at Chapel Hill $444,319 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct an in vivo, longitudinal study investigating microplastic exposure from clear aligner orthodontic therapy. The research will collect saliva and urine samples from 60 orthodontic patients before initiating comprehensive clear aligner treatment and at two subsequent timepoints...
- The National Institute of Dental and Craniofacial Research awarded the University of New Hampshire $299,950 on August 19, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop a functional smoothed deep learning approach combining deep neural networks and functional data analysis techniques for analyzing high-dimensional genetic data associated with orofacial clefts and predicting disease risk. The research will build and validate a functional smoothed deep...
- The National Institute of Dental and Craniofacial Research awarded the University of Southern California $481,739 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop three-dimensional organoid models representing the stepwise neoplastic evolution of head and neck squamous cell carcinoma. The recipient institution will create organoids directly from normal human oral tissues, patient-derived leukoplakia samples, and head and neck squamous cell...
- The National Institute of Dental and Craniofacial Research awarded The Regents of the University of Colorado, doing business as University of Colorado-Denver, $656,545 in project grant funding on August 24, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds research to characterize the spatial and functional architecture of recurrent oral squamous cell carcinoma by integrating immune cell distribution with bacterial localization, transcriptomics, and...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded $540,629 to the University of Massachusetts Lowell on August 15, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research investigating human oral host-pathogen interactions and dysbiosis modulation. The project, scheduled for completion by August 14, 2027, focuses on developing and validating an immunocompetent three-dimensional (3D) in vitro model...
- The National Institute of Dental and Craniofacial Research awarded the University of Massachusetts Lowell $100,676 on September 30, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop a three-dimensional in vitro human periodontal sulcus tissue model capable of reproducing healthy and disease states of gingivitis and periodontitis. The recipient will engineer a sustained tissue culture system that mimics key anatomical features of the gingival sulcus—including...
- The National Institute of Dental and Craniofacial Research awarded the University of Rochester $415,813 on July 7, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop a modular microphysiologic system (MPS) for culturing three-dimensional innervated salivary gland tissue mimetics in array format. The funded research will create a platform capable of static and optional perfused culture of organoids and tissues arranged in arrays, addressing a gap in current...
- The National Institute of Dental and Craniofacial Research awarded Loma Linda University $358,823 on September 11, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct structural-functional studies of gingipain biogenesis and localization in periodontitis research. The research addresses therapeutic gaps in managing periodontitis, a chronic disease linked to systemic diseases including atherosclerosis, rheumatoid arthritis, cancers, diabetes, and Alzheimer's...
The National Institute of Dental and Craniofacial Research awarded the University of North Carolina at Chapel Hill $682,398 under the Oral Diseases and Disorders Research program (CFDA 93.121) on August 1, 2026. The recipient will develop a predictive algorithm to identify individuals at high risk of developing long COVID based on high-resolution phenotyping of the immunologic, microbial, proteomic, and metabolomic landscape of the oral cavity during and after SARS-CoV-2 infection. The project builds on prior findings demonstrating oral immune dysregulation in early SARS-CoV-2 infection and exploits saliva as a biofluid for delineating SARS-CoV-2 oral biology, pathophysiology, and host-pathogen interactions. In Aim 1, the research team will determine salivary microbial, proteomic, metabolomic, and immune signatures associated with long COVID development in an established cohort of biobanked COVID-19 outpatients (n=355) combined with new enrollees (n=300) followed longitudinally, of which 30–37% have or will develop long COVID symptomatology. In Aim 2, the team will leverage a novel deep learning pipeline to identify salivary factors predictive of long COVID during acute infection and diagnostic of long COVID after infection. Work is performed in Chapel Hill, North Carolina, with a period of performance from August 1, 2026, through May 31, 2031. This assistance is categorized as a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $682.4k | 8/3/26 |