This $515,926 Project Grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) will fund research to develop an in vitro gingival (gum) tissue system to study the role of microbial communities on oral health and disease. The 5-year project, beginning June 1, 2024, will be conducted by the University of Massachusetts Lowell's Office of Research Administration-Lowell. The key objectives are: (1) developing and validating a microphysiological system to study oral...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $873,546 to the University of Texas Health Science Center at Houston to develop an "oral micro-drug factory" using engineered Limosilactobacillus reuteri bacteria to secrete the anti-inflammatory cytokine interleukin-10 (IL-10) for treating periodontitis. The goal is to locally administer the...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $656,315 to Temple University to study the impact of cyclic strain on the pathogenesis of oral microbes, particularly Candida albicans and denture-related microbiota. The goal is to mechanistically understand how biomaterial cyclic strain, driven by chewing forces, can influence the virulence and dysbiosis of oral...
This Project Grant award of $198,000.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support a research study at The Pennsylvania State University (Penn State) to examine how one's background and socioeconomic factors shape oral microbial diversity and determine the extent to which these microbes contribute to oral health differences in the United States. The study will utilize 16S ribosomal...
This federal Project Grant award of $241,500.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports research to identify diffusible small molecules that regulate the replication of the bacterium Porphyromonas gingivalis (P. gingivalis). The research aims to establish the identity of growth-promoting cues produced by different strains of P. gingivalis and the bacterium Veillonella parvula that...
This Project Grant award of $858,000 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to explore the mechanisms by which the bacterium Veillonella inhibits the hemolytic activity of the periodontal pathogen Porphyromonas gingivalis. The research aims to: 1) investigate how Veillonella's heme production suppresses P. gingivalis' hemolysis, and 2) determine how P. gingivalis regulates...
This Project Grant award of $248,627 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121) supports research to understand the role of T cell responses to the oral pathogen Aggregatibacter actinomycetemcomitans in the immunopathology of periodontal disease. The research aims to: 1) assess systemic T cell responses to this pathogen in human periodontal disease, and 2) determine the role of...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $442,750 to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to conduct research on the interactions between the bacterium Fusobacterium nucleatum and oral squamous cell carcinomas. The key objectives of this 2-year project are to: 1) identify tumor cell determinants that influence...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), funded under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to study essential genes in the oral pathobiont Fusobacterium nucleatum. The $429,000 award to the University of Texas Health Science Center at Houston aims to investigate the molecular basis for the essentiality of the FomA gene and systematically identify other essential genes in F. nucleatum. The goal...
This $431,750 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to decipher the mechanisms by which two proteins, AAFLP-1 and AADCUB, regulate the production of exopolysaccharide (PNAG) in the oral bacterium Aggregatibacter actinomycetemcomitans. The research aims to investigate how these two proteins, which are unique to A. actinomycetemcomitans, independently...