Project Grant R01DE035339
- The National Institute of Dental and Craniofacial Research awarded The Regents of the University of Colorado (University of Colorado-Denver) $552,009 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop autologous organoid and humanized mouse models with thymic T cell education capacity for testing head and neck cancer immunotherapy. The award funds development of stem cell-derived thymic organoids (STOs) and isogenic multicellular models generated...
- The National Institute of Dental and Craniofacial Research awarded the University of Pennsylvania $427,839 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop and validate a multimodal imaging platform integrating stimulated Raman scattering (SRS) microscopy with tissue immunofluorescence for spatially resolved metabolic mapping at single-cell resolution in human papillomavirus-positive head and neck squamous cell carcinoma tissue. The research...
- The National Institute of Dental and Craniofacial Research awarded $597,769 to the Trustees of Columbia University in the City of New York on August 3, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121, a Project Grant). The award funds development of an engineered hydrogel-patient-derived organoid platform with tunable viscoelastic properties designed to model oral epithelial dysplasia and recapitulate the biomechanics of dysplasia and oral squamous cell carcinoma...
- The National Institute of Dental and Craniofacial Research awarded The University of Texas MD Anderson Cancer Center $1,470,872 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to elucidate subclonal evolution and fitness dynamics in oral carcinogenesis. The research identifies and interrogates the functional importance of genomic events that drive subclonal selection as oral premalignant lesions (OPL) transform into oral squamous cell carcinoma (OSCC)....
- The National Institute of Dental and Craniofacial Research awarded the Regents of the University of Michigan $275,574 on January 1, 2029, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the evolution of pro-tumoral myeloid cells during the initiation of oral cancer in HPV-negative head and neck squamous cell carcinomas. The project develops a preclinical mouse model to study the transition from oral epithelial dysplasia to HNSCC, focusing on SOX2-driven...
- The National Institute of Dental and Craniofacial Research, part of the National Institutes of Health under the Department of Health and Human Services, awarded The University of Chicago $328,000 on August 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop and validate a microsimulation model of oral health lifetime outcomes and resource use in older adults. The project, titled "Development and Validation of the U.S. Oral Health Microsimulation...
- The National Institute of Dental and Craniofacial Research, within the Department of Health and Human Services National Institutes of Health, awarded $449,625 to the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center on May 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support basic and translational research on the role of immunomodulators IL-33 and SPRR in oropharyngeal candidiasis. The research investigates immunological mechanisms...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Illinois $249,000 on August 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop bone-like organoids that elucidate how immune responses influence craniofacial bone healing and regeneration. The recipient will establish bone-like organoids as predictive tools for craniofacial bone repair...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded The Washington University $427,625 on February 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds research to develop and evaluate radiation-guided theranostic agents for detecting and monitoring response to oral cancer treatment. The research leverages radiation-inducible antigens, specifically...
- The National Institute of Dental and Craniofacial Research awarded the University of Southern California $675,063 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research deciphering the conserved grammar of craniofacial enhancer function. The recipient will use the funding to investigate how mutations in gene regulatory elements (enhancers) lead to congenital craniofacial anomalies. The research employs two complementary approaches:...
The National Institute of Dental and Craniofacial Research awarded the University of Southern California $481,739 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop three-dimensional organoid models representing the stepwise neoplastic evolution of head and neck squamous cell carcinoma. The recipient institution will create organoids directly from normal human oral tissues, patient-derived leukoplakia samples, and head and neck squamous cell carcinoma tumors to investigate the role of MLL3 (KMT2C), a histone methyltransferase and frequently mutated gene in this cancer type, as an early driver of oral neoplastic evolution and anti-tumor immune regulation. The research applies both human organoid and murine models to examine molecular mechanisms of leukoplakia-associated neoplasia and MLL3-driven pathways, addressing the lack of viable human models for studying stepwise squamous epithelial transformation from dysplasia through carcinoma in situ to invasive disease. Work is performed in Los Angeles, California, with a period of performance from September 1, 2026, through May 31, 2031. This is a Project Grant, the standard NIH research project grant mechanism.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $481.7k | 9/1/26 |