Project Grant R16DE036179
- The National Institute of Dental and Craniofacial Research awarded the University of New Hampshire $299,950 on August 19, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop a functional smoothed deep learning approach combining deep neural networks and functional data analysis techniques for analyzing high-dimensional genetic data associated with orofacial clefts and predicting disease risk. The research will build and validate a functional smoothed deep...
- The National Institute of Dental and Craniofacial Research awarded the University of Southern California $703,242 on August 18, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the regulatory mechanisms of soft palate morphogenesis and cleft palate malformations. The funded research examines how the trigeminal nerve regulates soft palate development through molecular signaling pathways. The project tests three hypotheses: that trigeminal nerve-derived...
- The National Institute of Dental and Craniofacial Research awarded Cincinnati Children's Hospital Medical Center a project grant of $605,123 on June 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the regulation of palate development and innervation in the context of cleft palate pathology. The research addresses velopharyngeal insufficiency, a functional deficit affecting 20 to 40 percent of children who undergo surgical repair for cleft palate....
- The National Institute of Dental and Craniofacial Research awarded the University of Texas Health Science Center at Houston $400,000 on August 24, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121, assistance type: Project Grant R56DE036303). The recipient will investigate the function of TWIST1 and its regulatory pathway in craniofacial bone development, focusing on the genetic interaction between the epithelial-to-mesenchymal transition transcription factor TWIST1 and...
- The National Institute of Dental and Craniofacial Research awarded New York University $656,068 on August 3, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to fund research into the neuronal mechanisms of lingual mechanosensation and nociception. The research investigates the molecular identities and functional roles of oral mechanosensory neurons and their contributions to oral health and pain disorders. The work focuses on tongue-innervating trigeminal neurons and...
- The National Institute of Dental and Craniofacial Research awarded $234,000 to the University of Texas Health Science Center at Houston on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate decoy adhesion mechanisms by which the commensal bacterium Veillonella atypica shields oral epithelial cells from colonization and inflammatory damage by the pathogenic keystone species Porphyromonas gingivalis. The research dissects the molecular and...
- The National Institute of Dental and Craniofacial Research awarded the University of New Mexico $305,000 under the Oral Diseases and Disorders Research program (CFDA 93.121) on June 5, 2026. The award funds research into the mechanisms by which PRDM3 and PRDM16 chromatin modifiers control craniofacial cartilage development. The research uses genetic mouse models, in vitro cell culture systems, and molecular tools to test whether precise levels of these paralogs fine-tune Wnt/β-catenin...
- The National Institute of Dental and Craniofacial Research awarded the Stowers Institute For Medical Research $371,250 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the pathogenesis, phenotypic variation, and prevention of craniofacial anomalies. The project examines how genetic and environmental factors interact to produce craniofacial birth defects—conditions such as cleft lip and palate, micrognathia, and craniosynostosis that account...
- The National Institute of Dental and Craniofacial Research awarded Duke University $444,125 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate central nervous system and autonomic correlates of temporomandibular disorder pain. The research characterizes how altered brainstem circuit activity and brain glymphatic flow relate to autonomic dysfunction in patients with chronic painful temporomandibular disorder (TMD). The project measures...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded $128,191 to the University of California Irvine on May 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award supports a project grant (K99DE034828) to identify non-coding genetic sources of mammalian craniofacial variation and test their functional impact on facial morphogenesis. The research addresses the...
The National Institute of Dental and Craniofacial Research awarded the University of North Texas $142,235 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the relationship between tongue positioning and velopharyngeal insufficiency in individuals with velopharyngeal dysfunction secondary to cleft palate with or without cleft lip. The research addresses the persistent challenge that behavioral interventions to reduce hypernasality—a speech effect of velopharyngeal insufficiency—have not consistently improved outcomes despite a 70% success rate in physical and surgical management over the past fifty years. The proposed study will examine whether elevated tongue dorsum positioning, documented in phonetically nasalized vowels in typical speakers, can reduce oral airflow during production of pressure-sensitive sounds and thereby inform treatment strategies for patients who do not benefit sufficiently from palatal surgery or prosthesis, particularly those with mild hypernasality, motor speech disorders, or anatomical limitations. Work is performed at the University of North Texas Research and Innovation Division in Denton, Texas, with a period of performance from September 1, 2026, through August 31, 2030. The assistance type is a project grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $142.2k | 9/1/26 |