Project Grant R21DA062847
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, awarded a $118,656 Project Grant under CFDA 93.279 - Drug Use and Addiction Research Programs to the Ponce Medical School Foundation Inc. in Puerto Rico. The grant aims to study the influence of fear conditioning prior to cocaine self-administration on cocaine seeking behaviors in adult rats, with a focus on assessing the role of frontostriatal circuits in the co-occurrence of trauma and cocaine use disorder....
- This Project Grant award from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, under the Drug Use and Addiction Research Programs (CFDA 93.279), will provide $474,347 to Wake Forest University Health Sciences (WFUHS) to investigate the impact of nicotine and alcohol co-use on the abuse potential of cocaine in monkey models. The goal is to extend the study of cocaine misuse to include the co-use of nicotine and/or alcohol, examining behavioral and...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $1,240,766 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The University of Kentucky Research Foundation. The grant, titled "Targeting Immune Inflammation in Cocaine Use Disorder: A Human Laboratory Study with Pentoxifylline," aims to investigate whether targeting neuroimmune signaling can affect the response to cocaine use and serve as a...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, awarded a $790,937 Cooperative Agreement under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Research Foundation for the State University of New York (RF SUNY), doing business as Sponsored Projects Services. This award supports research to understand the genetic factors that contribute to the transition from recreational to problematic drug use, with the goal of uncovering biological...
- This $436,050 federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to investigate cell type and circuit-specific epigenetic mechanisms underlying cocaine addiction. The research will utilize a mouse model of repeated cocaine exposure to study how cocaine-induced molecular changes in specific brain regions and neuronal circuits lead to the development of addictive behaviors. The goal is to...
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) totaling $1,447,919.00 supports research on the "Cocaine Addition and the Need-State Hypothesis." The research project aims to test the hypothesis that addiction involves the hijacking of physiological need substrates, in addition to reward substrates. Specifically, the project will evaluate whether treatment with a Glucagon-Like Peptide-1...
- This $149,284 Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) to Vanderbilt University will fund research to understand how chronic cocaine use disrupts the neural processing of aversive, non-drug stimuli in the brain. The study aims to define the precise temporal parameters under which dopamine release modulates the activity of genetically-defined neuron populations in the nucleus accumbens, both at baseline and in...
- This federal Project Grant award of $1,159,396.00 was provided by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (CFDA 93.279 Drug Use and Addiction Research Programs), to Vanderbilt University. The grant will support research to understand how cocaine activates specific neuronal ensembles in the nucleus accumbens region of the brain and how epigenetic mechanisms, particularly the enzyme KAT2A, regulate the recruitment and maintenance of these...
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $153,988 to Vanderbilt University to conduct research on the neural mechanisms underlying changes in motivation for drug and non-drug rewards following repeated cocaine use. The project aims to use cellular resolution imaging in awake, behaving animals to investigate how cocaine self-administration alters the neural encoding of cocaine...
- This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), totaling $1,742,971 and commencing on April 15, 2025, aims to investigate the role of cannabinoids in modulating cocaine-induced inflammasome activation and epigenetic regulation in the intestine and brain during HIV/SIV infection. The primary objectives are to: 1) examine the impact of cocaine and HIV/SIV on inflammasome activation and its...
The National Institute on Drug Abuse (NIDA) awarded a $225,000 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Louisiana State University Health Sciences Center New Orleans. The grant will fund the validation of a novel preclinical rat model to study the combined effects of cocaine vapor inhalation and oral alcohol consumption. The research aims to develop an animal model that replicates key features of cocaine base use and its co-morbidity with alcohol use in humans. The project will investigate the physiological and behavioral impacts of concurrent cocaine vapor exposure and alcohol consumption, as well as analyze related blood-drug and blood-metabolite levels. This work is intended to support future R01 applications to further explore the neurobiological basis of cocaine base use and its interactions with other substances.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $225.0k | 8/21/25 |