This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is funding research at Vanderbilt University to investigate the circuit mechanisms underlying inflexible habitual behaviors following chronic cocaine use. The $136,929 award, effective from April 1, 2025 to March 31, 2027, supports experiments to: 1) determine how a history of cocaine self-administration alters dopamine release to promote habitual...
This Project Grant award of $1,159,396 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research at Vanderbilt University to investigate the molecular and epigenetic mechanisms underlying cocaine addiction. The research aims to understand how cocaine triggers the recruitment and maintenance of specific neuronal ensembles in the nucleus accumbens (NAc) that drive addictive behaviors. Key focus areas include examining...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), is providing $226,295.00 to the University of Texas at Austin to conduct research on the mechanisms by which cocaine affects striatal circuit activity and cocaine seeking behaviors. The research aims to: 1) Determine the necessity of striatal enkephalin in cocaine-induced adaptations in the striatopallidal circuit, by investigating how...
This federal Project Grant award of $162,486 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to understand the effects of concurrent chronic stress and cocaine self-administration on microglia activity and dendritic spine morphology in the medial prefrontal cortex, and how these changes influence drug-seeking behavior. The award, with a start date of December 3, 2024 and an ultimate completion date of April 30,...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $157,568 to Drexel University to elucidate corticolimbic circuit and neuroimmune mechanisms underlying HIV-induced dysregulation of reward-seeking behavior. The research aims to use optogenetic and chemogenetic techniques to stimulate the infralimbic cortex-nucleus accumbens shell circuit and modulate microglial function to rescue HIV-induced...
This Project Grant award, valued at $695,250.00 and awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to investigate the role of endothelial injury and myeloid cell migration in the activation of inflammasomes in HIV infection and cocaine exposure. The key objectives are to characterize myeloid cell populations in the brains of HIV-transgenic mice under chronic cocaine treatment, and evaluate the...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $148,568 to investigate the mechanisms of dopamine transmission and its role in reward-related behaviors. The award period runs from January 1, 2025 to July 31, 2027. The funded research aims to advance the mechanistic understanding of how dopamine signaling occurs at the subcellular level, given limitations in prior methodologies. The...
This Project Grant award of $1,447,919.00 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research on cocaine addiction and the "need-state hypothesis" at Pennsylvania State University's Milton S. Hershey Medical Center. The research aims to use an animal model to identify individual vulnerability to cocaine addiction early in the disease state, and explore the use of a known satiety agent, glucagon-like...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is funding research at Duke University to elucidate the function of the ventral tegmental area (VTA) circuits and their contribution to the learning and performance of motivated behaviors. The $629,844 award, with a project period from May 1, 2025 to February 28, 2030, will leverage bidirectional optogenetics, in vivo electrophysiology, photometry, and...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,996,709.00 to Trustees of Indiana University (doing business as Indiana University Indianapolis) to investigate the role of cortical excitatory projections in cocaine addiction. The key objectives of this 5-year research project are to: 1) examine the excitability of cortical pyramidal neurons in the supplementary motor cortex (M2...