Project Grant R01DA061568
- This federal Project Grant award of $758,218 from the National Institute on Drug Abuse (NIDA), part of the Drug Use and Addiction Research Programs (CFDA 93.279), supports research on the potential of nociceptin/orphanin FQ peptide (NOP) receptors as targets for novel pharmacotherapies to treat cocaine use disorder (CUD) in non-human primate models. The key products and services to be delivered under this award include: Examining how NOP receptors influence vulnerability to developing CUD...
- The National Institute on Drug Abuse (NIDA) awarded a $225,000 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Louisiana State University Health Sciences Center New Orleans. The grant will fund the validation of a novel preclinical rat model to study the combined effects of cocaine vapor inhalation and oral alcohol consumption. The research aims to develop an animal model that replicates key features of cocaine base use and its co-morbidity with alcohol...
- This $436,050 federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to investigate cell type and circuit-specific epigenetic mechanisms underlying cocaine addiction. The research will utilize a mouse model of repeated cocaine exposure to study how cocaine-induced molecular changes in specific brain regions and neuronal circuits lead to the development of addictive behaviors. The goal is to...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, awarded a $790,937 Cooperative Agreement under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Research Foundation for the State University of New York (RF SUNY), doing business as Sponsored Projects Services. This award supports research to understand the genetic factors that contribute to the transition from recreational to problematic drug use, with the goal of uncovering biological...
- This federal Project Grant award of $121,323.00 was provided by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant will support research by the University of North Carolina at Chapel Hill to investigate the structural and functional responses of nucleus accumbens microglia following long-access cocaine self-administration. The research aims to elucidate the role of microglia and...
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) totaling $1,447,919.00 supports research on the "Cocaine Addition and the Need-State Hypothesis." The research project aims to test the hypothesis that addiction involves the hijacking of physiological need substrates, in addition to reward substrates. Specifically, the project will evaluate whether treatment with a Glucagon-Like Peptide-1...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $1,240,766 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The University of Kentucky Research Foundation. The grant, titled "Targeting Immune Inflammation in Cocaine Use Disorder: A Human Laboratory Study with Pentoxifylline," aims to investigate whether targeting neuroimmune signaling can affect the response to cocaine use and serve as a...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, awarded a $118,656 Project Grant under CFDA 93.279 - Drug Use and Addiction Research Programs to the Ponce Medical School Foundation Inc. in Puerto Rico. The grant aims to study the influence of fear conditioning prior to cocaine self-administration on cocaine seeking behaviors in adult rats, with a focus on assessing the role of frontostriatal circuits in the co-occurrence of trauma and cocaine use disorder....
- This $105,076 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to investigate the neurocomputational basis of effort-based decision making (EBDM) in individuals with tobacco use disorder, tobacco and opioid use disorder, and healthy controls. The award will support research to characterize the neurocomputational basis of EBDM during a smoking cessation attempt. The project will computationally model...
- This Project Grant award of $405,230 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to advance NR4A1 as a novel target for treating cocaine use disorder. The key objectives are to: 1) Synthesize and screen derivatives of the NR4A1 agonist Cytosporone B to identify lead compounds, and 2) Establish milestones towards filing a commercially-viable Investigational New Drug (IND) application for an NR4A1-targeted...
This Project Grant award from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, under the Drug Use and Addiction Research Programs (CFDA 93.279), will provide $474,347 to Wake Forest University Health Sciences (WFUHS) to investigate the impact of nicotine and alcohol co-use on the abuse potential of cocaine in monkey models. The goal is to extend the study of cocaine misuse to include the co-use of nicotine and/or alcohol, examining behavioral and pharmacological interventions to decrease the reinforcing effects of cocaine, as well as the effects of chronic drug treatments in female and male monkeys self-administering cocaine, nicotine, and cocaethylene. This research aims to advance the understanding of neural and behavioral mechanisms of cocaine use disorder and potential treatment strategies, given the high rate of co-use with other substances.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $474.3k | 8/7/25 |