The National Institute on Drug Abuse (NIDA) has awarded a $492,000 Project Grant (CFDA 93.279 - Drug Use and Addiction Research Programs) to the University of Chicago to conduct a multidimensional study on the genetic and epigenetic factors underlying cocaine addiction. The 5-year project aims to: Perform high-resolution chromatin accessibility and DNA methylation profiling to delineate cell-type and circuit-specific epigenetic changes following cocaine self-administration in mice. This will...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is funding research at Vanderbilt University to investigate the circuit mechanisms underlying inflexible habitual behaviors following chronic cocaine use. The $136,929 award, effective from April 1, 2025 to March 31, 2027, supports experiments to: 1) determine how a history of cocaine self-administration alters dopamine release to promote habitual...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $180,606 to the Icahn School of Medicine at Mount Sinai to conduct research on cocaine-induced proteomic changes in the nucleus accumbens and their role in addiction behaviors. The 5-year project aims to elucidate the cell-type and circuit-specific synaptic proteome changes in response to cocaine, with the goal of identifying potential...
This $149,284 Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) to Vanderbilt University will fund research to understand how chronic cocaine use disrupts the neural processing of aversive, non-drug stimuli in the brain. The study aims to define the precise temporal parameters under which dopamine release modulates the activity of genetically-defined neuron populations in the nucleus accumbens, both at baseline and in...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,996,709.00 to Trustees of Indiana University (doing business as Indiana University Indianapolis) to investigate the role of cortical excitatory projections in cocaine addiction. The key objectives of this 5-year research project are to: 1) examine the excitability of cortical pyramidal neurons in the supplementary motor cortex (M2...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is funding research to investigate the molecular mechanisms underlying astrocytic CREB's regulation of cocaine drug-seeking behavior. The $180,646 award, spanning from December 2024 to November 2029, will be conducted by the Icahn School of Medicine at Mount Sinai. The research aims to elucidate the transcriptional and epigenetic regulation of astrocytes in...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), is providing $226,295.00 to the University of Texas at Austin to conduct research on the mechanisms by which cocaine affects striatal circuit activity and cocaine seeking behaviors. The research aims to: 1) Determine the necessity of striatal enkephalin in cocaine-induced adaptations in the striatopallidal circuit, by investigating how...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $121,323 to the University of North Carolina at Chapel Hill to investigate the structural and functional responses of nucleus accumbens microglia following long-access cocaine self-administration. The research aims to: 1) explore morphological responses of accumbens microglia and evidence of astrocyte membrane engulfment across abstinence in male...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), supports research to investigate the role of the reelin protein in the cellular and behavioral response to drugs of abuse, particularly cocaine. The $215,613 award to the University of Alabama at Birmingham aims to determine if reelin is required for cocaine-related behavioral adaptations and how reelin regulates membrane excitability to...
This Project Grant award of $1,447,919.00 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research on cocaine addiction and the "need-state hypothesis" at Pennsylvania State University's Milton S. Hershey Medical Center. The research aims to use an animal model to identify individual vulnerability to cocaine addiction early in the disease state, and explore the use of a known satiety agent, glucagon-like...