Cooperative Agreement U01DA060669
- This $436,050 federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to investigate cell type and circuit-specific epigenetic mechanisms underlying cocaine addiction. The research will utilize a mouse model of repeated cocaine exposure to study how cocaine-induced molecular changes in specific brain regions and neuronal circuits lead to the development of addictive behaviors. The goal is to...
- This Cooperative Agreement award from the National Institute on Drug Abuse (NIDA), under CFDA 93.279 - Drug Use and Addiction Research Programs, provides $944,888 in funding to Seattle Children's Hospital, doing business as Seattle Children's Research Institute, to conduct a 5-year research project titled "Deep Analysis of Transcriptome to Understand the Genetics of Substance Use Disorders in Rats". The project aims to improve the molecular interpretation of genome-wide association...
- The U.S. National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, awarded a $838,200 Cooperative Agreement under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Weill Medical College of Cornell University. The award, titled "JCOIN PHASE II ECONOMIC RESEARCH RESOURCE CENTER," will support the following key products and services over the award period from September 1, 2025 to May 31, 2030: Provide resources and evidence to support the...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $715,238 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the University of California, San Diego (UCSD) to conduct a "Multivariate Genome-Wide Association Analysis of Opioid-Related Traits in Half a Million Diverse Individuals." The project aims to improve understanding of the genetic basis of opioid use disorder (OUD) and related pre-addiction...
- This federal Project Grant award for $357,613 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to leverage large-scale whole-genome sequencing (WGS) data to identify novel rare and common genetic variants associated with substance use disorders (SUDs). The project, awarded to Yale University, has two key objectives: 1) to recover missing heritability in SUDs by analyzing WGS data from biobanks, and 2) to develop a novel...
- This Project Grant award of $405,230 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to advance NR4A1 as a novel target for treating cocaine use disorder. The key objectives are to: 1) Synthesize and screen derivatives of the NR4A1 agonist Cytosporone B to identify lead compounds, and 2) Establish milestones towards filing a commercially-viable Investigational New Drug (IND) application for an NR4A1-targeted...
- This federal Project Grant award of $795,090 from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to support research on the discovery of GPR52 ligand probes for the treatment of cocaine use disorder. The key products and services to be delivered under this award include: Establishing and validating GPR52-based cellular assays to identify small molecule GPR52 agonists Designing a...
- This federal Project Grant award, funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to examine the relationship between neighborhood conditions, neural circuits, and substance use behaviors across the early life course. The $2,314,254 award to The Research Foundation For The State University Of New York, doing business as Suny Downstate Health Sciences University, will fund a longitudinal study to investigate...
- This federal Project Grant award of $180,606.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund research at the Icahn School of Medicine at Mount Sinai to investigate the interplay between drug-induced long-term synaptic proteomic adaptations and the underlying transcriptional responses that drive these adaptations in a cell-type and circuit-specific manner within the brain's reward regions. The research aims to...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $1,240,766 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The University of Kentucky Research Foundation. The grant, titled "Targeting Immune Inflammation in Cocaine Use Disorder: A Human Laboratory Study with Pentoxifylline," aims to investigate whether targeting neuroimmune signaling can affect the response to cocaine use and serve as a...
The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, awarded a $790,937 Cooperative Agreement under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Research Foundation for the State University of New York (RF SUNY), doing business as Sponsored Projects Services. This award supports research to understand the genetic factors that contribute to the transition from recreational to problematic drug use, with the goal of uncovering biological mechanisms to aid in preventing and treating substance use disorders. Specifically, the project aims to increase the statistical power of a prior genome-wide association study in rats to discover additional gene variants linked to cocaine motivation and incentive sensitization. It will also investigate candidate genes identified through integrating multi-omic data related to cue-reactivity, another trait correlated with cocaine addiction. The ultimate completion date for this project is April 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $790.9k | 7/28/25 |