The University of Pennsylvania received a $527,837 Project Grant award from the National Institute on Drug Abuse, part of the Department of Health and Human Services, to study altered midbrain GABAergic circuitry and its role in driving greater cocaine self-administration. Specifically, the researchers will characterize the functional state of midbrain GABAergic circuitry and the disposition of the KCC2 potassium-chloride cotransporter during cocaine self-administration, extinction, and...
This $189,644 Project Grant award from the National Institute on Drug Abuse (NIDA), funded under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to characterize and functionally validate several transcript variants of the dopamine D3 receptor (DRD3) gene in the context of cocaine addiction. The project aims to: 1) Characterize the functions of DRD3 transcript variants using heterologous expression systems; and 2) Develop and validate neuron type-specific...
This $492,000 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports a multi-year research project at the University of Chicago. The project aims to elucidate the genetic and epigenetic factors underlying cocaine addiction through a multidimensional approach integrating genomics, epigenomics, neuroscience, and computational biology. Key objectives include: 1) Conducting high-resolution chromatin accessibility...
This federal Project Grant award, valued at $1,478,199.00 and funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to investigate the differential roles of prefrontal cortical interneurons in drug-seeking behavior after withdrawal from cocaine. The primary objectives are to: 1) monitor the activity of distinct interneuron subtypes in the infralimbic cortex during cocaine self-administration, 2) directly...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,785,632.00 over a 5-year period starting on July 15, 2024 to the University of Pittsburgh. The award will support research aimed at elucidating the role of astrocytic dopamine signaling in the nucleus accumbens and its impact on cue-conditioned motivated behaviors and cocaine relapse. The key objectives include characterizing the...
This federal Project Grant award, totaling $346,911, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award, valid from August 15, 2024 to July 31, 2026, will support a cross-species study to identify neurocognitive, genetic, and socioenvironmental risk factors for substance use disorders (SUDs). The key objectives of the project are to: 1) determine how early life environment influences neurocognitive development...
This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to advance the understanding of the role of the G9A/GLP chromatin modifying enzymes in the development of addictive behaviors. The $272,395 award, with a performance period from April 2025 to March 2027, will enable researchers at the University of California, San Francisco (UCSF) to: 1) identify specific surfaces on the G9A and GLP...
This $373,300 Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will support research to investigate the role of the nucleus accumbens (NAc) in learning and responding to reward-predictive cues. The research aims to enhance understanding of the neural activity dynamics in NAc that contribute to selective conditioned responses to reward-paired cues versus neutral cues. Using an auditory Pavlovian...
This $419,876 Project Grant was awarded on September 15, 2024 by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant will support preclinical research to investigate the therapeutic potential of targeting the neuropeptide S (NPS) receptor to mitigate opioid addiction. Specifically, the grant aims to: 1) Determine if NPS receptor-targeted molecules can reduce oxycodone self-administration and motivation to obtain the drug in...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $249,236 to Duke University to study the chromatin regulation of brain-derived neurotrophic factor (BDNF) in cocaine craving and relapse. The project aims to use innovative molecular genetic methods to define the chromatin architecture changes in dopamine neurons that accompany persistent alterations in gene expression, specifically focused on...
This Project Grant award from the National Institute on Drug Abuse (NIDA), funded under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to investigate the "need-state hypothesis" in cocaine addiction. The $685,856 award to Pennsylvania State University, specifically the Penn State Milton S. Hershey Medical Center, aims to use an animal model to identify early indicators of addiction vulnerability and test whether a glucagon-like peptide-1 (GLP-1) receptor agonist can reverse the aversive conditioned response and reduce drug seeking/taking behaviors in rats. The research involves three specific aims: 1) testing the effects of a GLP-1 agonist on cocaine-predictive taste cue responses and subsequent drug seeking/taking, 2) measuring brain activation patterns associated with this "need-state" in vulnerable vs. resistant rats, and 3) using site-specific infusions to interrogate the relevant neural circuits. This work seeks to better understand the neurobiological mechanisms underlying addiction development and explore potential early intervention strategies during the "preaddiction" stage.