This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research into the relationship between the gut microbiome and acute muscle loss in sepsis patients. The $950,664 award, with a project period from July 2024 to May 2026, will enable the University of Michigan to: 1) Determine how the gut microbiome and body composition interact to...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $458,907 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to the University of Kentucky Research Foundation. The grant, effective February 1, 2025 through January 31, 2030, will support research to determine if the gut microbiome of exercise-trained mice can be used to attenuate skeletal muscle atrophy. Specifically, the project aims to investigate if...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $216,113 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Weill Medical College of Cornell University. The grant, titled "Targeting GDF15-GFRAL Signaling in Mitochondrial Myopathies," will fund research to investigate the use of anti-GDF15 and anti-GFRAL antibodies to prevent and treat cachexia (muscle wasting) in a mouse model of mitochondrial myopathy. The...
This Project Grant award of $473,377 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research, supports research to modulate the stem cell niche and improve skeletal muscle regeneration. The key objectives are to: Interrogate how muscle cells arise and develop functional characteristics from human pluripotent stem cells (hPSCs) through analysis of myogenic commitment factors and inhibition of...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to develop specialized cryo-electron microscopy (cryo-EM) techniques to study the structures of mitochondrial complexes implicated in muscular myopathies. The $444,109 award to the Scripps Research Institute in La Jolla, CA will support the creation of methods to directly visualize endogenous...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research, totaling $820,142, will support research into the influence of early-life physical inactivity on adult muscle quality and function. The project aims to 1) investigate the effect of early-life physical inactivity in mice on muscle quality and function in adulthood, 2) determine the impact on the...
This federal Project Grant award for $459,820, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research into the role of mitochondrial respiration and bioenergetic metabolism in the regulation of growth plate chondrocyte differentiation and hypertrophy. The research aims to test the hypotheses that: 1) loss of the mitochondrial transcription factor TFAM in...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (CFDA 93.846 Arthritis, Musculoskeletal and Skin Diseases Research) provides $434,793 to the University of Arkansas to conduct research aimed at developing regenerative and rehabilitation strategies to reduce inflammation and improve muscle recovery following volumetric muscle loss (VML) injuries. The key objectives are to: 1) Determine the efficacy of endurance exercise in attenuating...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), funded under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $488,575.00 to the University of Arizona to conduct research on myosin binding protein-C (MYBP-C) and its role in regulating skeletal muscle contraction. The research aims to systematically determine the distinct functional and structural effects of SMYBP-C, FMYBP-C, and their...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $177,872 to the University of Houston System to study the interaction between human induced pluripotent stem cell (hiPSC)-derived endothelial cells and skeletal muscle progenitor cells, both in vitro and in vivo. The research aims to elucidate the underlying mechanisms governing the...