This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the use of collagenase to target collagen architecture in fibrotic skeletal muscle. The $123,424 award, made on September 26, 2024, will fund research to elucidate the mechanisms by which fibrotic collagen architecture drives muscle stiffness and impairs muscle stem...
This $439,791 federal Project Grant award was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant supports a research project at the University of Texas Southwestern Medical Center that aims to investigate the molecular mechanisms underlying myoblast fusion, which is essential for skeletal muscle development and regeneration. The key products and services...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $526,174 to Duke University to engineer heterocellular human skeletal muscle tissues. The goal is to recreate and study the native stem cell niche function in healthy skeletal muscle, which is critical for regeneration. The research will increase the cellular complexity of the...
This $531,109 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports the development of technologies to enable safe and effective gene editing in skeletal muscle. The key objectives are to: 1) maximize delivery of gene editing enzymes to muscle; 2) maximize the spread of editing enzymes across myofiber nuclei; 3) avoid sustained expression of...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will fund research into the mechanisms behind stretch activation (SA) and its role in skeletal muscle endurance. The primary objectives are to: 1) Test the hypothesis that SA is an alternative way to maintain force production that contributes to mammalian skeletal muscle endurance, 2) Determine...
This federal Project Grant award for $473,377, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA Program 93.846 Arthritis, Musculoskeletal and Skin Diseases Research, supports research to improve skeletal muscle regeneration using human pluripotent stem cells (hPSCs). The key objectives are to: 1) Interrogate how muscle cells arise and develop from hPSCs, 2) Understand how to support hPSC-derived muscle cells by building an in vitro niche, and...
This federal Project Grant award of $525,048, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to develop and optimize skeletal muscle delivery vehicles for the correction of genetic muscle diseases. The award supports research to 1) identify an optimal dosing strategy for lentiviruses pseudotyped with the muscle fusogenic proteins myomaker and myomerger, 2)...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $437,154 project grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to the University of Texas Health Science Center at Houston. This 5-year grant, effective July 1, 2024, will support research to investigate the role of skeletal muscle alpha-actin in skeletal myocyte differentiation and its disruption in intranuclear rod myopathy, a severe congenital myopathy. The project aims to...
The University of Vermont & State Agricultural College (UVM) was awarded a $201,960.00 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), a component of the U.S. Department of Health and Human Services, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant will fund research to create a novel zebrafish model system to study the role of individual myosin-binding protein C (MyBP-C) isoforms in...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $1,034,838 to support research into the regulation of stem cell niches in skeletal muscle. The primary aim is to investigate how neutrophil serine proteases, specifically neutrophil elastase, influence muscle stem cell activation and the overall muscle stem cell niche. The...