Project Grant R15AR084182

Award Date 9/25/24
Completion Date 8/31/27
Dollars Obligated $820K
Federal Grant Program
93.846
Assistance Type
Project Grant
Place of Performance
Oxford, OH 45056, USA
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This federal Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research, will support research to investigate the impact of early-life physical inactivity on adult muscle quality and function. The $820,142 award, effective from September 25, 2024 to August 31, 2027, will be conducted by Miami University in Oxford, Ohio. Key objectives include:

  1. Examining the effect of varying levels of early-life physical inactivity in mice on adult muscle quality and function phenotypes.
  2. Determining the underlying mechanisms by analyzing extracellular matrix regulation in adult muscle.
  3. Investigating the influence of early-life physical inactivity on the development of frailty and survival in aging mice.
  4. Providing undergraduate students exposure to biomedical research methods.

This research aims to characterize how early-life physical inactivity, equivalent to approximately 6 months in human childhood, may contribute to long-term muscle quality and physical function declines, as well as increased risk of frailty and reduced lifespan.

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