This $662,241 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to address the gap in validated outcome measures and natural history for mitochondrial myopathy (MM). The primary objectives are to: 1) obtain longitudinal data on the MM Composite Assessment Tool (MM-COAST) and MM Function Scale to define their minimum...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is for a study titled "Targeting Mitochondrial Permeability Transition to Attenuate Adverse Muscle Impact in Sepsis". The $193,188 award, effective from Sep 1, 2024 to Aug 31, 2026, will investigate the role of mitochondrial permeability transition (MPT) in skeletal muscle dysfunction...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 Biomedical Research and Research Training provides $311,168 to Accelerated Muscle Biotechnologies Consultants, L.L.C. to develop infrastructure and capabilities for myocardial and skeletal muscle imaging using synchrotron radiation at the Brookhaven National Labs facility. The key objectives are to: 1) acquire muscle small-angle X-ray scattering (MYSAXS) data comparable to current...
This Project Grant award of $488,575 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to understand how myosin binding protein-C (MyBP-C) regulates skeletal muscle contraction and the effects of mutations in genes encoding slow and fast MyBP-C paralogs. The University of Arizona, serving as the prime awardee, will use a novel "cut and paste"...
This Project Grant award of $522,714 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the role of stretch activation in mammalian skeletal muscle endurance. The research will focus on measuring the characteristics and mechanisms of stretch activation in mouse slow-twitch and fast-twitch muscle fibers, including determining the specific myosin...
The National Institute of General Medical Sciences (NIGMS) awarded a $344,400 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas Southwestern Medical Center to develop new tools and approaches for improving cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) imaging techniques. Specifically, the grant aims to: 1) Develop a sample preparation strategy to reduce electron-induced radiolysis of frozen-hydrated biological...
The Massachusetts Institute of Technology (MIT) has been awarded a $225,623 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant will support research to elucidate the critical mechanisms of intracellular collagen folding and quality control, with the goal of identifying new therapeutic targets for treating collagen-related diseases, known as...
The National Institute of General Medical Sciences (NIGMS) awarded a $3,999,999 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Icahn School of Medicine at Mount Sinai (ISMMS). The funding will support the purchase of a Glacios 2 cryo-electron microscope (cryo-EM) to enable ISMMS researchers to conduct advanced structural biology studies on diverse biological systems and disease mechanisms. The new cryo-EM instrument, equipped with a Falcon 4i...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $456,808 to the Buck Institute for Research on Aging to develop innovative mass spectrometry imaging (MSI) technologies and perform deep proteomic profiling of bone tissues. The goal is to spatially visualize changes in the extracellular matrix and glycans related to osteoarthritis,...
This Project Grant award of $438,000 from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) supports the development of conditional animal models of mitochondrial DNA diseases at the University of Texas at Austin. The project aims to use CRISPR gene editing tools to introduce precise edits in the mitochondrial genome of zebrafish, enabling the creation of the first conditional animal model for mitochondrial disorders like mitochondrial...