This $205,920 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research by the Regents of the University of Michigan to investigate the relationship between the gut microbiome and acute muscle loss in sepsis patients.
The key objectives are to:
- Determine the interaction between gut microbiota and body composition in predicting clinical outcomes among septic patients.
- Identify gut microbiota that predict acute muscle loss in sepsis patients.
The research aims to elucidate how specific gut bacteria and metabolic pathways influence the development of sepsis-induced muscle wasting, with the goal of enabling new therapeutic approaches to prevent and treat this condition. The project will leverage a retrospective cohort of 800 sepsis patients to characterize gut microbiome, body composition, and clinical outcomes, with a detailed analysis of a 300-patient subgroup.
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