This $843,630 Project Grant, awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research at the University of California, Irvine to improve skeletal muscle regeneration using human pluripotent stem cell (hPSC) transplantation therapies. The project aims to investigate how hPSCs can be directed to functionally mature muscle cells, and how the stem cell...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to investigate the novel role of HOX-expressing interstitial cells in muscle growth, homeostasis, and regeneration. The $557,357 award, effective March 14, 2025 through February 28, 2030, will be used by the University of Wisconsin-Madison to interrogate the potential of...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will provide $439,791.00 over a 5-year period from March 1, 2025 to February 28, 2030 to The University of Texas Southwestern Medical Center. The funding will support research to investigate the molecular mechanisms underlying myoblast fusion, which is essential for skeletal muscle development and...
This Project Grant award of $257,310 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research at the University of Illinois investigating the role of extracellular vesicles in mediating communication between endothelial cells and fibroblasts during skin wound healing. The research plan utilizes in vitro and in vivo models to examine how endothelial...
This $420,883 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research to improve muscle regeneration and restore function following serious traumatic injuries. The University of Missouri System, the prime recipient, will leverage its expertise in microvascular imaging, muscle biology, and biomaterials to investigate the role of fibroadipogenic...
This Project Grant award of $522,714 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the role of stretch activation in mammalian skeletal muscle endurance. The research will focus on measuring the characteristics and mechanisms of stretch activation in mouse slow-twitch and fast-twitch muscle fibers, including determining the specific myosin...
This Project Grant award of $151,471.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The project aims to investigate the use of collagenase enzyme to target and modify collagen architecture in fibrotic skeletal muscle, with the goal of reducing muscle stiffness and promoting tissue regeneration. Key research activities include: 1) using second...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $501,450 to The Washington University to conduct research on regulating tendon repair using stem cell-derived extracellular vesicles. The study aims to identify the specific subpopulation and active cargo molecules of extracellular vesicles that can enhance tendon healing and avoid...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $220,224 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to The Regents of the University of Colorado, operating as the University of Colorado, with a period of performance from July 4, 2024 to August 31, 2027. The funding will support the development of granular hydrogels for the controlled delivery of immunomodulatory and angiogenic extracellular vesicles to enhance...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is for a study titled "Targeting Mitochondrial Permeability Transition to Attenuate Adverse Muscle Impact in Sepsis". The $193,188 award, effective from Sep 1, 2024 to Aug 31, 2026, will investigate the role of mitochondrial permeability transition (MPT) in skeletal muscle dysfunction...