Project Grant R21AI178331

Award Date 4/24/25
Completion Date 3/31/27
Dollars Obligated $216K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Seattle, WA 98195, USA
Similar Awards
This $783,557 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate the molecular determinants and functions of bacterial polysaccharide cellular localization in Pseudomonas aeruginosa biofilms. The key products and services to be delivered include: Examining modifications to the Psl and Pel exopolysaccharides to determine if they exist in...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $948,482 to the University of Colorado-Denver to study the molecular mechanisms of the YbtPQ siderophore importer in antibiotic-resistant bacterial infections. The 5-year award, beginning on July 17, 2024, aims to define the substrate selectivity and inhibitory mechanisms of YbtPQ, as well as understand its...
This federal Project Grant award of $147,656 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports a multi-disciplinary analysis of the role of PagC, a bacterial outer membrane protein, in the biogenesis of outer membrane vesicles (OMVs) in Salmonella enterica subsp. Typhimurium. The research aims to leverage biophysical, biochemical, ultrastructural, and microbiological techniques to define...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $1,355,504.00 to Rensselaer Polytechnic Institute to study the respiratory processes and fitness of Bacteroides bacteria, which are the most abundant in the human gut. The research aims to investigate the complex respiratory chain of Bacteroides, identify the electron donor to the NUO-11 enzyme, determine the...
This $595,901 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to expand the understanding of biosynthetic mechanisms for natural antimicrobial peptides (AMPs). The overarching goal is to dissect the mechanisms of a novel biosynthetic gene cluster (BGC) that leads to AMP production, with a focus on ascribing roles of the BGC components in both the biosynthetic events yielding...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $870,531 in funding to the University of Notre Dame to conduct research focused on identifying the mycobacterial genes that control bacteriolysis, or bacterial cell lysis, within the macrophage cytoplasm. The research objectives are to determine if known virulence pathways protect mycobacteria from bacteriolysis in the...
This $371,150 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research to characterize a novel Brucella small RNA, called BSR7, that is critical for the cell envelope integrity of this pathogenic bacteria. The research aims to determine if deletion of BSR7 will attenuate Brucella abortus in both macrophage and animal infection models. Additionally, the project will...
This federal Project Grant award of $246,590 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is funding research to investigate the mechanism and therapeutic potential of "nucleus-forming" bacteriophages (phages) that infect Pseudomonas aeruginosa bacteria. The key objectives of this research are to: 1) determine the structure and function of the phage protein GP69 that mediates...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $189,150 to investigate the molecular mechanisms of the HtrA enzyme in the pathogenic bacterium Streptococcus pneumoniae. The research aims to elucidate the structural rearrangements and dynamics of the HtrA monomer, as well as the structural basis of HtrA oligomerization and substrate engagement. Led by the University of...
This federal Project Grant award of $382,500.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to support research into the functional and mechanistic role of LP17-encoded factors in host adaptation by the Lyme disease spirochete, Borrelia burgdorferi. The key objectives of the research are to: 1) Establish the importance of the BBD21 and BBD22 genes for copy number control of B. burgdorferi...

This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $216,165 to the University of Washington to characterize a novel cytochrome protein, designated as Cyt BP1, found in the pathogen Burkholderia pseudomallei and other persistent bacterial infections. The proposed research aims to:

  1. Determine the phenotype of disruption mutants encoding for Cyt BP1 orthologues in model organisms, 2) Characterize the catalytic function of Cyt BP1 in nitric oxide (NO) conversion, and 3) Elucidate the structure-function relationship of Cyt BP1. The findings from this study could provide key insights into the mechanism by which persistent pathogens, including the bioterrorism agent B. pseudomallei, evade host-produced NO and establish persistent infections. This award is expected to be completed by March 31, 2027.

Generated 5/13/25, 5:47 AM