This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support research to investigate the molecular determinants and functions of bacterial polysaccharide cellular localization in Pseudomonas aeruginosa biofilms. The primary goals are to examine different isoforms of the Psl and Pel exopolysaccharides, explore how the Sia system controls their localization to the cell surface, and dissect the biological consequences of exopolysaccharide localization and the contributions of cell-associated versus cell-released forms within the biofilm. The total award amount is $783,557 and the project period runs from February 25, 2025 to January 31, 2030. The award was granted to the University of Washington, which has a track record of conducting federally funded infectious disease research.
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