Project Grant R01AI175072
Award Date
7/12/24
Completion Date
6/30/29
Dollars Obligated
$383K
Federal Agency
National Institute of Allergy and Infectious Diseases
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Pullman, WA 99164, USA
Similar Awards
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $191,250 to support research on the role of genetic factors in antigenic variation of the VlsE surface protein of the Lyme disease spirochete, Borrelia burgdorferi. The goal is to decipher the mechanistic details of cis-acting factors involved in VlsE expression and gene conversion, which is a key mechanism for...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $509,130 to the University of South Florida to conduct research on the global virulence regulatory network in the Lyme disease pathogen Borrelia burgdorferi (BB). The key objectives are to: 1) define the regulon (set of genes) controlled by the BosR regulator and characterize the contributions of BosR-regulated...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $2,014,302 Project Grant under CFDA 93.855 Allergy and Infectious Diseases Research to Montana State University for the research project "Phage-Mediated Horizontal Gene Transfer in Borrelia burgdorferi". The grant aims to investigate how phages (viruses that infect bacteria) drive the horizontal transfer of genetic material between strains of the Lyme disease-causing bacterium B. burgdorferi, which is key to...
The Virginia Commonwealth University was awarded a $746,009 Project Grant from the Department of Health and Human Services National Institutes of Health National Institute of Allergy and Infectious Diseases. The grant falls under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research examining the cyclic-di-GMP signaling pathway and its role in the enzootic cycle of Lyme disease from November 18, 2022 through October 31, 2027. Specifically, the grant will fund...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $192,500.00 to the University of South Alabama to investigate the mechanisms of central nervous system invasion by the Lyme disease pathogen, Borrelia burgdorferi. The research aims to: Determine the role of the blood-cerebrospinal fluid barrier as a site for B. burgdorferi and immune cell entry into the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $299,933 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to L2 Diagnostics LLC, a for-profit biomedical research company based in Woodbridge, Connecticut. The project aims to develop a novel therapeutic using a secretory leukocyte protease inhibitor (SLPI) to mitigate Lyme arthritis and post-treatment Lyme disease syndrome. The award period runs from July 8, 2024 to June 30, 2026....
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $162,000.00 to The Johns Hopkins University to conduct research on understanding how the host protein epidermal growth factor (EGF) acts as an environmental cue to regulate gene expression in the Lyme disease-causing bacterium Borrelia burgdorferi. The research aims to characterize the binding of EGF to B....
The Project Grant award, with Federal Grant Award ID R41AI179571, is provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $300,000 award, effective July 17, 2024 through June 30, 2026, supports the development of a broad-spectrum prophylactic for tick-borne diseases, specifically Lyme disease and relapsing fever. The grantee, Planet Biotechnology Incorporated, will use a plant-based...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to characterize innate immune signaling pathways in the tick Ixodes scapularis. The $1,663,244 award, effective from March 1, 2025 to May 8, 2025, will be executed by President and Fellows of Harvard College, doing business as Harvard Medical School. The project will leverage cell culture-based methods and in vivo assays...
This $199,984 Project Grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to increase the fundamental understanding of the immune response to various Lyme disease antigens using bacterial outer membrane vesicles (OMVs) as a novel carrier system. The research objectives are to: 1) explore fusion proteins as a proof of concept to present full Borrelia burgdorferi (BB) antigens on OMVs, 2) determine the potential to express multiple BB antigen epitopes on...