The University of Colorado-Denver received a $189,150 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to investigate the structural and dynamic properties of Streptococcus pneumoniae's HtrA enzyme. This exploratory research aims to elucidate the molecular mechanisms behind HtrA's conformational changes and oligomerization, which are critical for the enzyme's role as a virulence factor in S. pneumoniae infection. The award period runs from March 1, 2025 to February 28, 2027. The proposed research will use advanced techniques like NMR and cryo-EM to provide the first detailed structural insights into this understudied branch of HtrA enzymes found in pathogenic gram-positive bacteria. This work could lead to a better understanding of S. pneumoniae infection processes and inform the development of potential therapeutic interventions.
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