This federal Project Grant award, valued at $637,275.00 and awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to uncover the mechanisms by which Gram-negative bacterial pathogens develop rapid tolerance to chemical stressors, such as antibiotics. The research aims to elucidate how these bacteria can inhibit the functioning of existing porin proteins in their outer membranes...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $948,482 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Colorado-Denver. The funding supports a 5-year research project to study the molecular mechanisms of the YbtPQ importer, a critical component of the bacterial siderophore-mediated metal uptake process. The project aims to define the substrate selectivity and inhibitory mechanisms of YbtPQ, as well as...
This $216,165 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to characterize a cytochrome protein found in the bacterial pathogen Burkholderia pseudomallei and other disease-causing microbes. The research aims to determine the role of this cytochrome in helping these pathogens evade the host immune system's nitric oxide defenses, a key mechanism for their persistence and...
This federal Project Grant award, with a total funding amount of $462,000.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project, titled "MICROBIOMES REGULATE NEUTROPHIL RESPONSES IN SEPSIS", aims to investigate how the human microbiome primes the immune system, specifically neutrophils, to influence patient responses and outcomes during sepsis. The research will explore...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is funding a research project focused on the discovery and engineering of microbial enzymes that can modulate peptidoglycan metabolites in the gut microbiome. The primary objectives are to identify highly active, secreted, and stable peptidoglycan-degrading enzymes (Aim 1) and develop genetically engineered probiotic...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop a new strategy for linking quantitative bacterial traits to host cell mutations. The $256,995 award to Tufts University School of Medicine will fund research to measure two key intracellular traits of the pathogen Legionella pneumophila - iron starvation and fitness - and use optical sequencing techniques to...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $749,417 to support research focused on developing novel bactericidal antibiotics to address the growing problem of multi-drug resistant pathogens. The research team at Harvard University aims to synthesize and evaluate new antibiotic candidates that target the lipoprotein transport pathway in Gram-negative...
This federal Project Grant award of $637,729 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the molecular mechanisms underlying the activation and regulation of essential bacterial cell wall synthase enzymes. The overarching goal is to develop a detailed mechanistic understanding of these enzymes, which are critical for bacterial cell wall assembly and represent...
This federal Project Grant award of $451,292 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) seeks to uncover neuronal mechanisms that orchestrate metabolic adaptations to bacterial infections, with a focus on delineating the role of the brain-liver axis in modulating these responses. The research aims to better understand how neuronal and hepatic (liver) processes regulate circulating lipid levels...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $506,394.00 in funding to the University of Chicago to conduct research on bacterial cholesterol-dependent cytolysins (CDCs) and their role in activating the NLRP3 inflammasome. The research aims to define the specific molecular and cellular mechanisms by which CDCs can reorganize host organelles to stimulate the NLRP3...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is funding research focused on understanding respiratory and fitness processes in the Bacteroides bacteria, which are abundant in the human gut. The $2,734,799 award to Rensselaer Polytechnic Institute will support investigations across three key areas: 1) studying the NUO complex, which is critical for generating the proton gradient that powers transport processes in Bacteroides; 2) exploring the acquisition and remodeling of the essential respiratory component menaquinone; and 3) examining the NRFHA complex, which may protect Bacteroides against nitric oxide in the gut. The project aims to reveal new insights into Bacteroides physiology that could have implications for human health. A $250,007 sub-award to the University of Chicago will support activities like genetic construct development, gnotobiotic mouse studies, RNA sequencing analyses, and creation of barcoded transposon sequencing banks to contribute to the overall research objectives.