Project Grant R21AG093287
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $176,201 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of California, Irvine. The grant, with an award date of July 15, 2025 and an ultimate completion date of March 31, 2030, will fund research to investigate the molecular changes in aging female urethral striated muscle and develop potential treatments for urethral dysfunction,...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $400,000.00 in funding to Baylor College of Medicine to conduct research on the cellular and molecular mechanisms that govern bladder aging. The key objectives are to: Define the role of ribosomal and translational quality control machinery in maintaining bladder homeostasis and response to urinary tract infections in young, aged, and genetically-modified mouse models. This includes using a 3D...
- The University of California, San Francisco (UCSF) was awarded a $474,043 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to conduct research on the utilization, outcomes, and complications associated with third-line treatments for refractory overactive bladder (OAB) in older and frail older adults. The study aims to better understand how factors such as age, frailty, race, socioeconomic status, and provider experience impact the use and...
- The National Institute on Aging (NIA) awarded a $489,509 Project Grant (CFDA 93.866 - Aging Research) to the Magee-Womens Research Institute And Foundation to conduct research on steroid hormone pathways regulating benign prostate hyperplasia (BPH) and lower urinary tract symptoms (LUTS) associated with aging. The 2-year project aims to: Identify proteins and pathways involved in promoting smooth muscle relaxation and bladder voiding that are dysregulated in aged mouse prostate models and...
- This federal Project Grant award of $690,451 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research on the role of bladder fibroblasts in regulating bladder function. The University of Pittsburgh will conduct studies to investigate the contractile properties of suburothelial fibroblasts and their contribution to the formation of bladder rugae, as well as the involvement of...
- This federal Project Grant award of $1,321,600 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports research to investigate the cellular mechanisms underlying recurrent vaginal prolapse in women after prolapse surgery. The research, to be conducted by The Leland Stanford Junior University from July 1, 2025 to June 30, 2027, aims to address the knowledge gap around altered tissue microenvironment and cellular function in the vaginas of women...
- This $472,793 Project Grant was awarded by the National Institutes of Health (NIH) National Institute on Aging under the Aging Research federal grant program (CFDA 93.866) to the University of Texas at Arlington. The grant aims to develop an automated device to study reproductive aging in the C. elegans nematode model, with a focus on understanding how the nutrient-sensing mTORC2 pathway regulates reproductive senescence independently from somatic aging. The research will investigate the roles...
- This federal Project Grant award of $3,427,292 from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a comprehensive scientific investigation into sex differences in frontotemporal dementia (FTD). The research, conducted by The Regents of the University of California, San Francisco (UCSF), aims to deeply characterize understudied female-specific biology to unlock new insights into FTD pathophysiology, precision treatments, and novel dementia risk and resilience targets....
- This $4,765,698 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will fund a research study by the University of California, Santa Barbara to investigate the effects of endocrine aging on spatial navigation ability and its neuronal systems. The project will enroll 240 cognitively normal midlife adults, with a balanced distribution of pre-, peri-, and post-menopausal women, and use immersive virtual environments and brain imaging to elucidate how...
- The University of Texas at Dallas received a $734,639 Project Grant (CFDA 93.866 - Aging Research) from the National Institute on Aging to conduct research on identifying age and injury-dependent mechanisms of elastic fiber dynamics in the murine vagina. The goal is to determine how age and vaginal injury impact the production and function of elastic fibers, which are critical for maintaining vaginal integrity and healing. The research will explore the use of the drug minoxidil to induce elastic...
This federal Project Grant award for $431,750, provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), supports research at the University of California, Irvine (UCI) to investigate the mechanisms of age-related urethral dysfunction and potential anti-fibrogenic therapies. The research aims to evaluate the effect of aging on the female mouse urethra, including functional, morphometric, and transcriptomic analyses. Key areas of focus include understanding the role of fibro-adipogenic progenitor (FAP) cells and the fibrosis-related factor connective tissue growth factor (CTGF) in urethral aging and dysfunction. The project is scheduled to run from Sep 18, 2025 to Aug 31, 2026 and seeks to provide insights that may lead to new treatments for urinary incontinence in aging women.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $431.8k | 9/16/25 |