Project Grant RF1AG096477
- This federal Project Grant award of $3,221,450.00 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to define how neuronal hyperexcitability in the retrosplenial cortex (RSC) contributes to the development of Alzheimer's disease (AD)-related behavioral deficits in mouse models. The research aims to determine the effect of inhibiting RSC layer 5 cells on spatial memory and navigation, as well as when hyperexcitability emerges in these cells across different AD...
- The National Institute on Aging (NIA) awarded a $1,558,726 Project Grant under the Aging Research program (CFDA 93.866) to the University of Pittsburgh. The grant, titled "MENOBRAIN: A Longitudinal Investigation of Menopause and Brain Health," will conduct a 5-year study to elucidate the brain and cognitive changes that occur during the perimenopause phase of the menopause transition, and the factors contributing to these changes. The study will recruit 224 women in the late...
- This federal Project Grant award of $145,566 from the National Institute on Aging (CFDA 93.866 - Aging Research) is supporting research at the Icahn School of Medicine at Mount Sinai to investigate how the brain accumulates and utilizes "cognitive maps" - internal neural representations that enable flexible behavior and memory recall. The research aims to provide insights into the neuronal coding deficits underlying cognitive decline, with the goal of informing therapeutic...
- This federal Project Grant award of $203,278.00, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), will fund research to understand the behavioral and neurobiological mechanisms underlying age-related shifts in motivation and their impact on daily life activity participation in older adults. The research will employ a multilevel, multimodal approach, utilizing behavioral, psychophysiological, neuroimaging, and naturalistic assessment methods to...
- This federal Project Grant award of $815,215 from the National Institute on Aging (CFDA 93.866 - Aging Research) is supporting a multi-modal imaging study to understand sex-based differences in brain circuitry and Alzheimer's disease (AD) pathology. The research, led by Yale University, has two key aims: 1) leveraging a new prospective cohort to test the impact of sex and sex-based factors like reproductive period and APOE genotype on functional brain networks and tau progression in...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $220,132 to Albert Einstein College of Medicine to design a spatial navigation intervention protocol informed by region-specific brain activation for individuals at risk for dementia. The project aims to 1) determine the feasibility of a virtual reality-based spatial navigation training protocol, and 2) explore training-induced neuroplasticity in older adults participating in the virtual reality...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at Iowa State University to study the relationship between the menopause transition and accelerated cerebrovascular aging in women. The $405,155 award, commencing on September 1, 2025, will support a 2-year project to determine differences in cerebral pulsatility, cerebral blood flow, and associated vascular contributors between pre-, peri-, and post-menopausal women. The research aims...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will support a $185,074 research study conducted by the University of California, Berkeley. The goal of the study is to examine how brain network connectivity is associated with Alzheimer's disease (AD) risk, longitudinal pathology accumulation, and aging. The researchers will use positron emission tomography (PET) imaging and resting-state functional MRI (rs-fMRI) to investigate the mechanisms of how...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $4,055,366 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of Southern California (USC). The grant, awarded on September 15, 2025, aims to investigate the impact of exposure to endocrine-disrupting persistent organic pollutants during the menopausal transition on cognition, brain activity, and Alzheimer's disease (AD) biomarkers. The project...
- This $749,108 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to understand how memory failures lead to decision failures across the lifespan. The research will use computational and neurobiological approaches to measure the influence of different types of memory - item, context, and statistical learning - on decision-making choices. The project will examine these questions in cognitively normal older adults through behavioral tasks,...
This $4,765,698 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will fund a research study by the University of California, Santa Barbara to investigate the effects of endocrine aging on spatial navigation ability and its neuronal systems. The project will enroll 240 cognitively normal midlife adults, with a balanced distribution of pre-, peri-, and post-menopausal women, and use immersive virtual environments and brain imaging to elucidate how changes in sex hormones during the menopausal transition impact navigation and related brain circuits. This interdisciplinary study aims to address critical gaps in understanding the aging brain and inform the use of navigation as a tool for detecting Alzheimer's disease risk. The award period runs from August 5, 2025 to July 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $4.8m | 8/4/25 |