The National Institute on Aging (NIA) awarded a $439,535 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of Colorado from September 30, 2023 to September 29, 2025. This grant will fund research to investigate the interplay between active smooth muscle cell contractility and passive extracellular matrix mechanics in the aging bladder, with the goal of gaining insight into the development of lower urinary tract symptoms in older adults. The University...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $400,000.00 in funding to Baylor College of Medicine to conduct research on the cellular and molecular mechanisms that govern bladder aging. The key objectives are to: Define the role of ribosomal and translational quality control machinery in maintaining bladder homeostasis and response to urinary tract infections in young, aged, and genetically-modified mouse models. This includes using a 3D...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,018,167 to Beth Israel Deaconess Medical Center, Inc. (BIDMC) to study the mechanisms behind benign prostatic hyperplasia (BPH) and non-responsiveness to steroid 5a-reductase inhibitor (5ARI) therapy. The research aims to elucidate how decreased expression of the SRD5A2 enzyme and...
The National Institute on Aging (NIA) awarded a $391,101 Project Grant under the Aging Research program (CFDA 93.866) to The Ohio State University to develop a novel nonsteroidal and nonhormonal agent that reverses menopause-related loss of genital epithelial integrity and function. The research aims to define the mechanism of action, optimize delivery, and establish the long-term safety profile of an EFNA3-mimetic agonist peptide (EFNA3-MAP) administered intravaginally to restore genital...
This Project Grant award, valued at $629,250.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to examine the role of hyaluronic acid (HA) in the pathobiology of benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTS). The primary objectives are to characterize the relationship between HA,...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $387,201 in funding to Middlebury College to conduct research on the memory-enhancing effects of testosterone in the aging male brain. The key objectives are to: 1) Determine the relative effects of testosterone and aging on place and response learning in male rats, 2) Assess the role of brain-derived neurotrophic factor (BDNF) in regulating testosterone-induced changes in spatial...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $462,923 to Albany Medical College to develop new mouse models of andropause (age-related decline in male sex hormones) for Alzheimer's disease and related dementia (ADRD) research. The primary goals are to: Determine the natural time course of endocrine aging in wild-type mice and mouse models of ADRD (Aim 1). Model endocrine aging in male mice via gonadectomy and gradual androgen...
This $1,350,373 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to elucidate the role of lipid accumulation and foam cells in benign prostate disease. The project, conducted by Old Dominion University and its research foundation, aims to: 1) investigate the impact of the cytokine CXCL17 on the prostatic immune environment in mice...
The National Institute on Aging (CFDA 93.866 Aging Research) awarded a $389,852 Project Grant to Dignify Therapeutics, LLC to develop novel drug formulations for treating urinary incontinence (UI) and overactive bladder (OAB) symptoms in the elderly. The grant supports a research project to create new intravesical (bladder-instilled) drug therapies that can block pain-sensing neurons and provide long-term relief of UI and OAB for elderly patients who are unresponsive to current treatments. The...
The University of California, San Francisco (UCSF) was awarded a $474,043 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to conduct research on the utilization, outcomes, and complications associated with third-line treatments for refractory overactive bladder (OAB) in older and frail older adults. The study aims to better understand how factors such as age, frailty, race, socioeconomic status, and provider experience impact the use and...