Project Grant R56AG076501

Award Date 9/15/23
Completion Date 8/31/24
Dollars Obligated $474K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
San Francisco, CA 94143, USA
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The National Institute on Aging (CFDA 93.866 Aging Research) awarded a $389,852 Project Grant to Dignify Therapeutics, LLC to develop novel drug formulations for treating urinary incontinence (UI) and overactive bladder (OAB) symptoms in the elderly. The grant supports a research project to create new intravesical (bladder-instilled) drug therapies that can block pain-sensing neurons and provide long-term relief of UI and OAB for elderly patients who are unresponsive to current treatments. The...
The National Institute on Aging (NIA) awarded a $451,000 Project Grant under the Aging Research federal grant program (CFDA 93.866) to The Regents of the University of California, San Francisco (UCSF) to conduct research aimed at improving incontinence support for family caregivers of persons living with dementia (PLWD). The study will utilize focus groups, interviews, and participatory photography to better understand the unique urinary incontinence (UI) support needs, preferences, and...
The National Institute on Aging (NIA) awarded a $439,535 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of Colorado from September 30, 2023 to September 29, 2025. This grant will fund research to investigate the interplay between active smooth muscle cell contractility and passive extracellular matrix mechanics in the aging bladder, with the goal of gaining insight into the development of lower urinary tract symptoms in older adults. The University...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $400,000.00 in funding to Baylor College of Medicine to conduct research on the cellular and molecular mechanisms that govern bladder aging. The key objectives are to: Define the role of ribosomal and translational quality control machinery in maintaining bladder homeostasis and response to urinary tract infections in young, aged, and genetically-modified mouse models. This includes using a 3D...
The University of California, San Francisco (UCSF) received a $123,309 project grant award from the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) federal grant program. The award will fund research to investigate how fatty acids regulate gene expression and cellular processes during fasting and aging. The project aims to identify the molecular mechanisms by which fatty acids modulate the translation of mRNAs involved in metabolic pathways, and determine how...
This $3,841,367 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports research to better understand the role of the TBK1 protein kinase and associated autophagy pathways in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The University of California, San Francisco (UCSF) will use advanced stem cell models and proteomics to: 1) identify novel TBK1 substrates and characterize the effects of TBK1 loss on...
The National Institute on Aging (NIA) awarded a $656,000 Project Grant (CFDA 93.866 - Aging Research) to The Regents of the University of California, San Francisco (UCSF) to investigate the role of hyperalgesic priming in chronic pain experienced by the elderly. The research aims to: 1) establish that aged rats exhibit nociceptor plasticity (priming) and determine if it is associated with systemic inflammation, and 2) identify the mechanisms underlying priming in the elderly, including the...
This $176,201 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at the University of California, Irvine to investigate urethral dysfunction and urinary incontinence in women. The key objectives are to (1) identify molecular changes in aging female urethral tissue, and (2) explore the role of the fibrogenic factor CTGF in age-related urethral muscle...
The National Institute on Aging (NIA) awarded a $489,509 Project Grant (CFDA 93.866 - Aging Research) to the Magee-Womens Research Institute And Foundation to conduct research on steroid hormone pathways regulating benign prostate hyperplasia (BPH) and lower urinary tract symptoms (LUTS) associated with aging. The 2-year project aims to: Identify proteins and pathways involved in promoting smooth muscle relaxation and bladder voiding that are dysregulated in aged mouse prostate models and...
This Project Grant award of $1,214,399 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund the development of a novel minimally invasive electrode strategy to better target the posterior tibial nerve for the treatment of overactive bladder (OAB). The University of Wisconsin System is the prime awardee, with subawards to Neuronoff Inc. for device fabrication and Case...

The University of California, San Francisco (UCSF) was awarded a $474,043 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to conduct research on the utilization, outcomes, and complications associated with third-line treatments for refractory overactive bladder (OAB) in older and frail older adults. The study aims to better understand how factors such as age, frailty, race, socioeconomic status, and provider experience impact the use and effectiveness of treatments like onabotulinumtoxinA, peripheral tibial nerve stimulation, and sacral neuromodulation in this vulnerable patient population. The goal is to develop an individualized prognostic tool to help guide treatment decision-making and improve outcomes for older and frail adults suffering from refractory OAB. The grant award period runs from September 15, 2023 through August 31, 2024.

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