This Project Grant award of $690,451 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research at the University of Pittsburgh to investigate the role of fibroblasts in bladder mucosal function. The research aims to define the molecular mechanisms that allow specialized suburothelial fibroblasts to reform the bladder mucosa into rugae (folds) when the bladder...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate the role of urothelial cells in bladder sensory function and pain signaling. The $521,019 award to The Medical College of Wisconsin, Inc. aims to functionally and molecularly identify the sensory neuron populations that respond to urothelial cell...
The National Institute on Aging (NIA) awarded a $451,000 Project Grant under the Aging Research federal grant program (CFDA 93.866) to The Regents of the University of California, San Francisco (UCSF) to conduct research aimed at improving incontinence support for family caregivers of persons living with dementia (PLWD). The study will utilize focus groups, interviews, and participatory photography to better understand the unique urinary incontinence (UI) support needs, preferences, and...
The National Institute on Aging (NIA) awarded a $439,535 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of Colorado from September 30, 2023 to September 29, 2025. This grant will fund research to investigate the interplay between active smooth muscle cell contractility and passive extracellular matrix mechanics in the aging bladder, with the goal of gaining insight into the development of lower urinary tract symptoms in older adults. The University...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $400,000.00 in funding to Baylor College of Medicine to conduct research on the cellular and molecular mechanisms that govern bladder aging. The key objectives are to: Define the role of ribosomal and translational quality control machinery in maintaining bladder homeostasis and response to urinary tract infections in young, aged, and genetically-modified mouse models. This includes using a 3D...
This Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate mechanisms for enhancing the motor function of fecal continence muscles to improve fecal incontinence in patients. The $862,002 award to The Medical College of Wisconsin, Inc. will fund a 5-year study to characterize the fatigability of continence muscles and determine...
This federal Project Grant award for $153,540 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research at Columbia University to perform human genome-wide association studies (GWAS) to identify genetic risk variants associated with urinary tract infections (UTIs). The research aims to discover novel genes and cell types involved in immune...
This $625,060 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund research to elucidate the roles of distinct spinal cord cell types in mediating interstitial cystitis (IC)/bladder pain syndrome (BPS). The research, conducted by The Washington University in St. Louis, will use chemogenetics and optogenetics approaches to determine the...
The University of California, San Francisco (UCSF) was awarded a $474,043 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to conduct research on the utilization, outcomes, and complications associated with third-line treatments for refractory overactive bladder (OAB) in older and frail older adults. The study aims to better understand how factors such as age, frailty, race, socioeconomic status, and provider experience impact the use and...
The National Institute on Aging (CFDA 93.866 Aging Research) awarded a $389,852 Project Grant to Dignify Therapeutics, LLC to develop novel drug formulations for treating urinary incontinence (UI) and overactive bladder (OAB) symptoms in the elderly. The grant supports a research project to create new intravesical (bladder-instilled) drug therapies that can block pain-sensing neurons and provide long-term relief of UI and OAB for elderly patients who are unresponsive to current treatments. The...