The National Institute on Aging (NIA) awarded a $2,244,471 Project Grant under CFDA 93.866 (Aging Research) to Oregon Health & Science University (OHSU) to develop a first-in-class, CNS-penetrant small molecule agonist for G protein-coupled receptor 39 (GPR39) as a potential treatment for vascular cognitive impairment and dementia (VCID). The 3-year project from September 2023 to August 2026 will use in vitro and in vivo assays to identify lead compounds, determine their safety and...
This Project Grant award in the amount of $234,750 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award will fund research at the University of Missouri System to investigate the role of altered adhesion molecules in cerebrovascular dysfunction during aging, particularly related to cerebral small vessel disease and associated cognitive decline....
This federal Project Grant award of $768,427.00 from the National Institute on Aging (CFDA 93.866 Aging Research) supports a 3-year longitudinal study to determine the mechanisms linking midlife vascular risk factors with the early loss of brain tissue structure and cognitive function. The study aims to (1) investigate the early drivers of increased cerebrovascular pulsatility, (2) evaluate the spatial and temporal relationship between cerebrovascular pulsatility and brain tissue...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a research project at the University of Wisconsin - Madison to elucidate the cerebrovascular disease pathways that contribute to cognitive decline. The $640,906 grant, awarded on June 1, 2025, will leverage existing longitudinal data from over 2,000 participants to reprocess MRI data and provide a detailed spatial characterization of intracranial vascular stiffness and neurovascular flow tone...
The Oregon Health & Science University was awarded a three-year, $3.956 million project grant from the National Institutes of Health National Institute on Aging under the Aging Research program (CFDA 93.866). The grant will support research into the role of G protein-coupled receptor 39 in age-related vascular cognitive impairment. Specifically, the university researchers will test the hypothesis that endothelial-pericyte EET/GPR39 signaling plays a protective role against aging- and small...
The National Institute on Aging, part of the Department of Health and Human Services, awarded $2,459,487 under its Aging Research grant program (CFDA 93.866) to Seattle Children's Hospital on May 15, 2022 for a project concluding on April 30, 2025. The award will support research using in vivo multi-photon imaging techniques to investigate age-related impairment of venous drainage in deep gray and white matter regions of the mouse brain. Specifically, the researchers will test hypotheses about...
This federal Project Grant award of $2,398,590 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to investigate the role of altered brain microcirculation and capillary endothelial cell energetics in the development of vascular cognitive impairment and dementia (VCID) observed in Alzheimer's disease (AD) and related dementias. The multidisciplinary...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) totaling $683,367 aims to develop novel chemogenetic mouse models for studying cerebral hypoperfusion and vascular contributions to cognitive impairment and dementia (VCID). The award will support the creation of genetically-engineered mouse lines that allow for precise, adjustable control of brain pericyte contractility and capillary blood flow. This will enable in-depth...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $4,361,625 to The Washington University to establish a "VCID Center Without Walls for Understanding and Leveraging Small Vessel Cerebrovascular Disease Mechanisms in ADRD". The project aims to leverage new technologies like multi-omics biomarkers and single-cell/spatial transcriptomics to investigate the complex mechanisms underlying cerebral small vessel disease (CSVD) and vascular...
This $4.8 million project grant from the National Institutes of Health's National Institute on Aging Aging Research program (CFDA 93.866) will fund research into vascular contributors to blood-brain barrier permeability and regional white matter hyperintensity progression in asymptomatic individuals ages 40-50. The Johns Hopkins University will study how periventricular and deep white matter hyperintensities independently progress and influence clinical outcomes, and how increasing blood-brain...