This $1,521,356 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will fund a study to examine cerebrovascular reactivity (CVR) as a biomarker for vascular contributions to cognitive impairment and dementia (VCID) in patients with the rare genetic condition CADASIL. The University of Wisconsin-Madison is the prime awardee, with sub-awards to the Johns Hopkins University, University of Maryland-Baltimore, and Butler Hospital. The study will leverage a...
This Project Grant award of $5,949,022, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to identify novel therapeutic targets for treating cerebral amyloid angiopathy (CAA) and vascular contributions to cognitive impairment and dementia (VCID). The research, led by the Jackson Laboratory with sub-awards to Emory University, Rush...
This Project Grant award of $654,910 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to identify the molecular mechanisms underlying the contribution of cerebrovascular disease (CVD) pathologies to Alzheimer's disease and related dementias (AD/ADRD) in older adults. The award supports research at Rush University Medical Center to generate and analyze transcriptomic and proteomic data from white matter tissue samples, complementing existing data from gray matter. This...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $770,502 to The Regents of the University of California, San Francisco (UCSF) from May 1, 2025 to April 30, 2030. The project aims to understand the molecular mechanisms by which collagen IV regulates TGF-beta signaling in a mouse model of cerebral small vessel disease (CSVD), a...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), provides $776,503 to The General Hospital Corporation (Massachusetts General Hospital) to investigate the role of perivascular inflammation and vascular remodeling in cerebral small vessel diseases (CSVD), which can lead to intracerebral hemorrhage. The project will leverage autopsy cases and mouse...
The National Institute on Aging (NIA) awarded a $2,244,471 Project Grant under CFDA 93.866 (Aging Research) to Oregon Health & Science University (OHSU) to develop a first-in-class, CNS-penetrant small molecule agonist for G protein-coupled receptor 39 (GPR39) as a potential treatment for vascular cognitive impairment and dementia (VCID). The 3-year project from September 2023 to August 2026 will use in vitro and in vivo assays to identify lead compounds, determine their safety and...
This federal Project Grant award, issued by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $4,693,249 to the University of California, Los Angeles (UCLA) to conduct research on defining the molecular spectrum of white matter vascular lesions that drive vascular cognitive impairment and dementia (VCID). The project aims to develop a better understanding of...
The National Institute on Aging (NIA) awarded a $471,885 Project Grant (CFDA 93.866 - Aging Research) to Oregon Health & Science University (OHSU) from June 1, 2025 to May 31, 2027. The project aims to investigate the mechanisms underlying brain vascular endothelial cell (BVEC) disruption following vascular brain injury, which can contribute to vascular cognitive impairment and dementia (VCID). Specifically, the project will test hypotheses related to how the glycosaminoglycan hyaluronan and...
This Project Grant award for $2,398,590.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of brain microcirculation and capillary endothelial cell energetics in the development of vascular cognitive impairment and dementia (VCID) observed in Alzheimer's disease (AD) and AD-related dementias. The...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,908,677 to Dignity Health's St. Joseph's Hospital and Medical Center to conduct an integrative computational multimodal research project. The project aims to disentangle the pathophysiologic heterogeneity of age-related white matter hyperintensities (WMH) and expand the discovery of genetic contributions to WMH. Key objectives include deriving disease-specific WMH spatial patterns using...