This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a research project at the University of Wisconsin - Madison to elucidate the cerebrovascular disease pathways that contribute to cognitive decline. The $640,906 grant, awarded on June 1, 2025, will leverage existing longitudinal data from over 2,000 participants to reprocess MRI data and provide a detailed spatial characterization of intracranial vascular stiffness and neurovascular flow tone dynamics. The goal is to determine the impact of vascular disease processes, including vascular stiffness and decreased flow tone, on brain tissue integrity and cognition, both in the presence and absence of Alzheimer's disease pathology. The findings are expected to provide new insights into the specific cerebrovascular disease pathways leading to vascular contributions to cognitive impairment and dementia, which can inform future treatment strategies for age-related cognitive decline.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $640.9k | 5/30/25 |