Project Grant R01AG089562

Award Date 6/1/25
Completion Date 3/31/30
Dollars Obligated $641K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Madison, WI 53715, USA
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This federal Project Grant award of $768,427.00 from the National Institute on Aging (CFDA 93.866 Aging Research) supports a 3-year longitudinal study to determine the mechanisms linking midlife vascular risk factors with the early loss of brain tissue structure and cognitive function. The study aims to (1) investigate the early drivers of increased cerebrovascular pulsatility, (2) evaluate the spatial and temporal relationship between cerebrovascular pulsatility and brain tissue...
This Project Grant award in the amount of $234,750 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award will fund research at the University of Missouri System to investigate the role of altered adhesion molecules in cerebrovascular dysfunction during aging, particularly related to cerebral small vessel disease and associated cognitive decline....
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $4,692,540 to Northwestern University to develop advanced MRI techniques to directly assess cerebral microvascular pulsatility on widely available 3T MRI systems. The research aims to investigate the relationship between cerebral microvascular pulsatility and the global burden of cerebral small vessel disease (CSVD) as an MRI biomarker of brain injury. The successful completion of this...
The National Institute on Aging awarded a $4.6 million Project Grant to Cornell University under the Aging Research program (CFDA 93.866) to develop new imaging techniques for measuring microvascular blood flow in Alzheimer's disease and related dementia models. The award will support the design of an adaptive excitation source for 2-photon and 3-photon fluorescence microscopy to simultaneously measure blood flow speeds in approximately 300 cortical or 50 deep white matter microvessels. This...
This federal Project Grant award, with ID K25AG090707, was provided by the National Institute on Aging (NIA) under the Aging Research grant program (CFDA 93.866). The $136,778 award supports research conducted by Wake Forest University Health Sciences (WFUHS) aimed at investigating the impacts of cerebral microbleeds, a manifestation of small vessel disease, on brain networks and cognitive impairment. The key objectives are to: 1) utilize advanced brain network modeling to quantify the...
This Project Grant award, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), will fund a research project at the University of California, San Diego (UCSD) to quantify the lifetimes of neurovascular proteins in the central nervous system under healthy conditions, aging, and a tauopathy-based model of Alzheimer's disease. The $437,875 award, effective January 1, 2025 through December 31, 2026, will employ stable isotope labeling, non-enzymatic vessel isolation, and mass...
This $9,631,026 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program will fund research to investigate the impact of atherosclerosis on the brain's microvasculature and its relationship to Alzheimer's disease (AD) pathology. The award to Northwestern University will support a comprehensive analysis of the structural, molecular, and...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) provides $471,885 to Oregon Health & Science University (OHSU) to conduct research focused on understanding the mechanisms underlying brain vascular endothelial cell (BVEC) disruption following vascular brain injury (VBI). The research aims to: 1) Test the hypothesis that high molecular weight hyaluronan (HMW HA) inhibits BVEC ferroptosis through a CD44-dependent mechanism; 2)...
This $715,801 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at Duke University to elucidate the causal role of endothelial cells and perivascular macrophages in exacerbating postoperative delirium and the onset of Alzheimer's disease and related dementias in aging and hypertension. The overarching goal is to expand understanding of vascular risk factors and neurovascular unit dysfunction in hypertension and postoperative delirium,...
The National Institute on Aging (NIA) awarded a $790,491 Project Grant under the Aging Research federal grant program (CFDA 93.866) to The University of Texas Health Science Center at San Antonio (UTHSCSA) for the "VASCULAR IMAGING BIOMARKER RELATIONSHIPS TO ALZHEIMER'S DISEASE (VIBRA)" project. The grant aims to create standardized, computerized methods for quantifying cerebral small vessel disease biomarkers on brain MRI scans across diverse Alzheimer's Disease Research Center (ADRC)...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a research project at the University of Wisconsin - Madison to elucidate the cerebrovascular disease pathways that contribute to cognitive decline. The $640,906 grant, awarded on June 1, 2025, will leverage existing longitudinal data from over 2,000 participants to reprocess MRI data and provide a detailed spatial characterization of intracranial vascular stiffness and neurovascular flow tone dynamics. The goal is to determine the impact of vascular disease processes, including vascular stiffness and decreased flow tone, on brain tissue integrity and cognition, both in the presence and absence of Alzheimer's disease pathology. The findings are expected to provide new insights into the specific cerebrovascular disease pathways leading to vascular contributions to cognitive impairment and dementia, which can inform future treatment strategies for age-related cognitive decline.

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