Project Grant RF1NS128135
Award Date
7/15/22
Completion Date
4/30/25
Dollars Obligated
$4.8M
Funding Federal Agency
National Institute on Aging
Awarding Federal Agency
National Institute of Neurological Disorders and Stroke
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Maryland, USA
Similar Awards
The National Institutes of Health National Institute on Aging awarded $4,575,712 under the Aging Research program (CFDA 93.866) to The Washington University from May 2022 to April 2025. The award will support research into white matter metabolism in the context of aging, white matter hyperintensities, and Alzheimer's disease. Investigators will apply quantitative positron emission tomography imaging techniques to measure cerebral oxygen consumption, blood flow, oxygen extraction fraction, and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,125,393.00 to conduct an integrative computational multimodal study on age-related white matter hyperintensities (WMH). The award aims to disentangle the pathophysiologic heterogeneity of WMH and its link to conditions like stroke, cognitive decline, and dementia in the aging population. The study will leverage machine learning techniques to derive distinct, disease-specific WMH spatial...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) in the amount of $801,348 provides funding to The Johns Hopkins University to investigate the impact of obesity on brain microvascular and lymphatic vessel dysfunction, and their relationship to cognitive impairment. The university will use newly developed magnetic resonance imaging (MRI) techniques to assess abnormalities in cerebral blood vessels, perivascular spaces, lymphatic...
This $3,967,524 project grant from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research into the vascular contribution to white matter lesions and motor dysfunction in Alzheimer's disease and related dementias. The grantee, Rutgers, The State University of New Jersey, will analyze post-mortem brain tissues from Alzheimer's patients exhibiting early-stage motor deficits. Researchers will investigate pathogenic mechanisms of motor dysfunction in rodent models of...
This $640,906 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to elucidate the role of cerebrovascular disease (CVD) processes in contributing to cognitive decline and Alzheimer's disease (AD) pathology. The project aims to utilize advanced neuroimaging techniques to characterize specific CVD factors, such as vascular stiffness and neurovascular flow dynamics, and evaluate their impact on brain tissue integrity and cognition in...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, is for $476,993 over a period of 2 years from August 1, 2024 to July 31, 2026. The project aims to develop novel qualitative and quantitative methods to measure white matter hyperintensities (WMH) on low-field portable MRI (PMRI) devices. This will involve creating a WMH...
This $471,885 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at Oregon Health & Science University (OHSU) to investigate the mechanisms underlying brain vascular endothelial cell (BVEC) disruption following vascular brain injury (VBI). The project aims to test the hypothesis that hyaluronan (HA) protects BVECs from ferroptosis, a form of programmed cell death, through a CD44-dependent mechanism. Specific objectives include...
The Johns Hopkins University was awarded a $2,399,582 Project Grant from the National Institute on Aging (CFDA 93.866 Aging Research) to study extracellular vesicles derived from the brain as potential biomarkers for Alzheimer's disease. The 3-year grant, which begins on September 1, 2023, aims to identify specific cell surface markers and molecular signatures on brain-derived extracellular vesicles that could be used for early disease detection, monitoring, and understanding Alzheimer's...
This $239,758 Project Grant, awarded by the National Institute on Aging under the Aging Research federal grant program (CFDA 93.866), will fund the development of a microphysiological system that models the interactions between the brain, meninges, and lymphatic system in both healthy and Alzheimer's disease conditions. The research team, led by Virginia Polytechnic Institute & State University, will integrate three tissue-engineered models (of the human brain, lymph node, and meninges) into...
This $790,491 project grant awarded by the National Institute on Aging (Aging Research, CFDA 93.866) aims to create standardized, computerized methods for quantifying cerebral small vessel disease (SVD) biomarkers from brain MRI data across large, diverse Alzheimer's disease research cohorts. The primary goals are to: 1) develop reliable deep learning models to measure SVD biomarkers like microbleeds, white matter hyperintensities, and enlarged perivascular spaces; 2) relate these SVD biomarkers...