This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a research project at the University of Wisconsin - Madison to elucidate the cerebrovascular disease pathways that contribute to cognitive decline. The $640,906 grant, awarded on June 1, 2025, will leverage existing longitudinal data from over 2,000 participants to reprocess MRI data and provide a detailed spatial characterization of intracranial vascular stiffness and neurovascular flow tone...
This $9,631,026 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program will fund research to investigate the impact of atherosclerosis on the brain's microvasculature and its relationship to Alzheimer's disease (AD) pathology. The award to Northwestern University will support a comprehensive analysis of the structural, molecular, and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will provide $433,159 to the University of Maryland, Baltimore to conduct research on the role of pericytes in regulating brain blood flow and neurological function. The 5-year project, beginning August 1, 2024, will investigate the novel "pericyte chloride clamp" mechanism that...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) provides $471,885 to Oregon Health & Science University (OHSU) to conduct research focused on understanding the mechanisms underlying brain vascular endothelial cell (BVEC) disruption following vascular brain injury (VBI). The research aims to: 1) Test the hypothesis that high molecular weight hyaluronan (HMW HA) inhibits BVEC ferroptosis through a CD44-dependent mechanism; 2)...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $770,502 to conduct research on cerebral small vessel disease (CSVD) and vascular contributions to cognitive impairment and dementia (VCID). The 5-year project, awarded to the Regents of the University of California, San Francisco, aims to understand the molecular...
This federal Project Grant award of $768,427.00 from the National Institute on Aging (CFDA 93.866 Aging Research) supports a 3-year longitudinal study to determine the mechanisms linking midlife vascular risk factors with the early loss of brain tissue structure and cognitive function. The study aims to (1) investigate the early drivers of increased cerebrovascular pulsatility, (2) evaluate the spatial and temporal relationship between cerebrovascular pulsatility and brain tissue...
This federal Project Grant award of $2,398,590 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to investigate the role of altered brain microcirculation and capillary endothelial cell energetics in the development of vascular cognitive impairment and dementia (VCID) observed in Alzheimer's disease (AD) and related dementias. The multidisciplinary...
This $4,693,249 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program aims to define the molecular spectrum of white matter vascular lesions that drive vascular cognitive impairment and dementia (VCID). The research will characterize the progression from cerebral small vessel disease to cortical disconnection, identify molecular pathways regulating...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), provides $776,503 to The General Hospital Corporation (Massachusetts General Hospital) to investigate the role of perivascular inflammation and vascular remodeling in cerebral small vessel diseases (CSVD), which can lead to intracerebral hemorrhage. The project will leverage autopsy cases and mouse...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $4,692,540 to Northwestern University to develop advanced MRI techniques to directly assess cerebral microvascular pulsatility on widely available 3T MRI systems. The research aims to investigate the relationship between cerebral microvascular pulsatility and the global burden of cerebral small vessel disease (CSVD) as an MRI biomarker of brain injury. The successful completion of this...