Project Grant RF1AG077731

Award Date 5/15/22
Completion Date 4/30/25
Dollars Obligated $2.5M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Seattle, WA 98101, USA
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The National Institute on Aging awarded a $4.6 million Project Grant to Cornell University under the Aging Research program (CFDA 93.866) to develop new imaging techniques for measuring microvascular blood flow in Alzheimer's disease and related dementia models. The award will support the design of an adaptive excitation source for 2-photon and 3-photon fluorescence microscopy to simultaneously measure blood flow speeds in approximately 300 cortical or 50 deep white matter microvessels. This...
The National Institutes of Health National Institute on Aging awarded $4,575,712 under the Aging Research program (CFDA 93.866) to The Washington University from May 2022 to April 2025. The award will support research into white matter metabolism in the context of aging, white matter hyperintensities, and Alzheimer's disease. Investigators will apply quantitative positron emission tomography imaging techniques to measure cerebral oxygen consumption, blood flow, oxygen extraction fraction, and...
The National Institute on Aging (NIA) awarded a $471,885 Project Grant (CFDA 93.866 - Aging Research) to Oregon Health & Science University (OHSU) from June 1, 2025 to May 31, 2027. The project aims to investigate the mechanisms underlying brain vascular endothelial cell (BVEC) disruption following vascular brain injury, which can contribute to vascular cognitive impairment and dementia (VCID). Specifically, the project will test hypotheses related to how the glycosaminoglycan hyaluronan and...
This $1,919,387 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to assess the impact of reduced cerebral blood flow and neurovascular coupling on brain function and homeostasis in aging. The project aims to use a novel computational homeostatic modeling (HOMOD) approach to calculate regional brain tissue and capillary blood levels of CO2, O2, and pH in young and elderly subjects. The research will utilize calibrated fMRI and fMRS...
This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $416,480 to the University of Washington to map the landscape of the aged human brain and develop neurodegenerative disease models. The award will fund a two-phase research project that aims to: 1) identify molecular drivers of brain aging by applying explainable artificial intelligence (XAI) methods to human brain datasets, and 2) manipulate these aging drivers in human induced pluripotent stem...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $640,906 to the University of Wisconsin - Madison to elucidate the cerebrovascular disease pathways that contribute to cognitive decline. The project aims to utilize advanced neuroimaging techniques to characterize the impact of vascular disease processes, including vascular stiffness and decreased flow tone, on brain tissue integrity and cognition in the presence...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $663,000 to the University of Texas Health Science Center at Houston to conduct research on the role of cellular senescence in driving sex-specific outcomes of small vessel disease and post-stroke cognitive impairment. The research aims to understand the chronic neurological consequences of small vessel disease following stroke, and evaluate whether delayed treatment strategies targeting the...
Duke University has been awarded a $4,537,430 Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, to support research under the Aging Research program (CFDA 93.866). The grant will fund a study from September 2022 to August 2025 to examine the role of cellular senescence on postoperative neuroinflammation. Specifically, the researchers will use a mouse model of orthopedic fracture to determine how senescent cell burden exacerbates systemic...
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The National Institute on Aging, part of the Department of Health and Human Services, awarded $2,459,487 under its Aging Research grant program (CFDA 93.866) to Seattle Children's Hospital on May 15, 2022 for a project concluding on April 30, 2025.

The award will support research using in vivo multi-photon imaging techniques to investigate age-related impairment of venous drainage in deep gray and white matter regions of the mouse brain. Specifically, the researchers will test hypotheses about the region-specific deterioration of principal cortical venules, which are essential for draining blood from deeper tissues, and how dysfunction of associated capillary pericytes contributes to reduced blood flow during aging. The award also includes testing whether vasoconstriction and impaired flow in these venule networks can be alleviated by fasudil, a drug targeting rho kinase. The Allen Institute will assist with specific aims involving 3-photon imaging experiments and analysis of deep cortical layer and white matter vessel blood flow data for comparison across imaging systems. Outcomes aim to further understanding of the microvascular basis of white matter degeneration and whether age-related flow impairment is amenable to therapeutic modulation.

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