The National Institute on Aging, part of the Department of Health and Human Services, awarded $2,459,487 under its Aging Research grant program (CFDA 93.866) to Seattle Children's Hospital on May 15, 2022 for a project concluding on April 30, 2025. The award will support research using in vivo multi-photon imaging techniques to investigate age-related impairment of venous drainage in deep gray and white matter regions of the mouse brain. Specifically, the researchers will test hypotheses about the region-specific deterioration of principal cortical venules, which are essential for draining blood from deeper tissues, and how dysfunction of associated capillary pericytes contributes to reduced blood flow during aging. The award also includes testing whether vasoconstriction and impaired flow in these venule networks can be alleviated by fasudil, a drug targeting rho kinase. The Allen Institute will assist with specific aims involving 3-photon imaging experiments and analysis of deep cortical layer and white matter vessel blood flow data for comparison across imaging systems. Outcomes aim to further understanding of the microvascular basis of white matter degeneration and whether age-related flow impairment is amenable to therapeutic modulation.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $2.5m | 5/13/22 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
12864SUBS | Allen Institute | Project Grant RF1AG077731 | $250.7k | 11/30/22 |