This $1,623,119 project grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research characterizing Alzheimer's amyloid-beta oligomer structures through May 2025. The grantee, Georgia Tech Research Corporation, will use solid-state nuclear magnetic resonance and cryo-electron microscopy to achieve high-resolution structural characterization of a unique 150 kDa amyloid-beta oligomer. Researchers will obtain a...
This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 - Aging Research, totaling $393,731, supports research to investigate the conditions leading to the aggregation of amyloid-beta (Aβ) peptides in the brain during metabolic stress and spreading depolarization. The research team at the University of South Florida will use a multiscale modeling approach, including high-resolution microscopy, antibody staining, and analysis of paralysis phenotypes in C. elegans, to...
The National Institute on Aging (NIA) awarded a $514,862 Project Grant (CFDA 93.866 - Aging Research) to Neuroindx, a for-profit, woman-owned small business, to develop an on-chip functional assay for identifying candidate microtubule-binding drugs to treat Alzheimer's Disease and related disorders (ADRDs). The goal of the project is to create an in vitro assay that can replicate key features of the neuronal microtubule microenvironment and use kinesin-based readouts to measure the ability of...
The National Institute on Aging (NIA) awarded a $619,681 Project Grant (CFDA 93.866 - Aging Research) to The Leland Stanford Junior University (Stanford University) to develop innovative tools for studying the complex genetic interactions underlying Alzheimer's disease (AD) pathogenesis. The project, titled "Combinatorial Perturbation with Multi-Omics Readout to Dissect Etiology of Alzheimer's Disease Using Stem Cell and In Vivo Models", will create a toolkit combining gene-editing...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop a new blood-based biomarker for the early detection and monitoring of Alzheimer's disease (AD). The $431,826 award, made on September 15, 2024, will fund the development of monoclonal antibodies to detect a newly discovered, neurotoxic amyloid-beta (Aβ) peptide dimer that is specific to AD pathology in the brain. The project involves the University of Wollongong conducting...
The National Institute on Aging (NIA) awarded a $1,783,700.00 Project Grant under the Aging Research program (CFDA 93.866) to the University of Illinois to develop novel blood-brain barrier permeable multimodal imaging agents for the diagnosis of neurodegenerative diseases, with a focus on Alzheimer's disease and related dementias. The 3-year grant aims to employ organic and inorganic chemical design principles to generate diagnostic agents capable of detecting protein aggregation,...
This Project Grant award of $372,690 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to discover the heterogeneous causal pathophysiology of Alzheimer's disease (AD). The project will develop new statistical methods to uncover how amyloid-beta, tau accumulation, and cognition are causally related in different AD subpopulations. The goal is to reveal optimal treatment windows and target groups for therapies that reduce amyloid-beta or...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $472,695 project grant to 3D Bioanalytix, Inc. to develop a blood-based diagnostic test for early detection and differentiation of neurodegenerative diseases such as Alzheimer's and Parkinson's. The project leverages the company's Covalent Protein Painting (CPP) platform technology to detect and identify misfolded protein aggregates that characterize these diseases. This novel...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,667,706 to Emory University for research understanding the functional impacts of amyloid-β variants in Alzheimer's disease using human brain organoids. The three-year award beginning August 1, 2022 will support combining expertise in brain organoid modeling, spectroscopic analysis, and cryo-electron microscopy to identify strain-specific patterns of...
This Project Grant award of $328,000 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports the Alzheimer's Disease Organelle Proteome Task (ADOPT) pilot phase. The interdisciplinary research team, led by Drs. Biao Wang and Danielle Swaney at the University of California, San Francisco, will use a genetic organelle tagging approach to rapidly purify lysosomes from neurons in wild-type and Alzheimer's disease mouse models. A suite of mass spectrometry experiments will then...