Project Grant RF1AG079256

Award Date 8/1/22
Completion Date 7/31/25
Dollars Obligated $4.7M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Atlanta, GA 30322, USA
Similar Awards
This $1,623,119 project grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research characterizing Alzheimer's amyloid-beta oligomer structures through May 2025. The grantee, Georgia Tech Research Corporation, will use solid-state nuclear magnetic resonance and cryo-electron microscopy to achieve high-resolution structural characterization of a unique 150 kDa amyloid-beta oligomer. Researchers will obtain a...
This $147,656 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to Emory University aims to develop the first human locus coeruleus (LC) organoid model to study the role of the LC in the earliest stages of Alzheimer's disease (AD). The key products and services to be delivered under this grant include: Validating the structure and function of the LC organoids and combining them with cortical organoids to define LC-cortex connectivity and norepinephrine...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders provides $2,683,965.00 to Brigham & Women's Hospital Inc. to develop and optimize an improved all-human cellular system for studying Alzheimer's disease (AD) and age-related dementias (ADRDs). The key objectives are to: Define the delivery conditions for introducing patient blood cells and plasma...
This $200,323 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research by the University of South Florida to investigate the aggregation of amyloid-beta (Aβ) peptides during metabolic stress and spreading depolarization events in the brain. The project will utilize multiscale modeling, high-resolution microscopy, antibody staining, and paralysis phenotype testing in C. elegans to determine how physiochemical changes...
The National Institute on Aging (NIA) awarded Emory University a $528,876 Project Grant under the Aging Research federal grant program (CFDA 93.866) to develop new analytical tools that can identify more Alzheimer's disease (AD) and AD-related dementia (ADRD) risk genes by integrating genome-wide association study (GWAS) data with transcriptome-wide association study (TWAS) and proteome-wide association study (PWAS) data across multiple brain tissues. The key products and services to be...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research on the impact of brain lipoprotein structure and composition on amyloid beta metabolism and Alzheimer's disease. The $2,335,492 award to Battelle Memorial Institute's Pacific Northwest National Laboratory will fund a 5-year study to assess how differences in apolipoprotein E (APOE) isoforms affect brain lipoprotein distribution, composition, and ability to bind amyloid beta. The...
This $1,010,081 federal Project Grant award from the National Institute on Aging (under CFDA 93.866 - Aging Research) supports a multi-year research project by Emory University focused on identifying potential "goldilocks zone" immune modulatory therapies for Alzheimer's disease. The overarching goal is to systematically evaluate the liabilities and benefits of different immune system manipulations in preclinical models of amyloid pathology, with the aim of finding interventions that...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the cell-type specific impacts of Alzheimer's disease (AD) pathology within the medial temporal lobe. The $103,304 award, effective August 1, 2024 through July 31, 2025, will utilize advanced viral tracing methods and microscopy imaging to identify and reconstruct 3D entorhinal cortex-CA1 neuron circuits that are susceptible to AD pathology propagation. After...
This $500,000 Project Grant was awarded on September 15, 2024 by the National Institute on Aging (CFDA 93.866 Aging Research program) to Neucyte Inc., a minority-owned small business specializing in advanced biomedical research and development. The funding will support the development of a miniaturized "mini-brain" microphysiological system (MPS) platform using Alzheimer's disease (AD) patient-derived cells. The goal is to create a scalable, reproducible in vitro brain model that can...
This three-year, $3,027,312 Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research into the role of hippocampal inhibitory interneurons in novel memory formation and how this process is disrupted in Alzheimer's disease. Specifically, the awardee, Georgia Tech Research Corporation, will record electrical activity from inhibitory and excitatory neurons in mice and selectively stimulate parvalbumin-positive interneurons to test...

This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,667,706 to Emory University for research understanding the functional impacts of amyloid-β variants in Alzheimer's disease using human brain organoids. The three-year award beginning August 1, 2022 will support combining expertise in brain organoid modeling, spectroscopic analysis, and cryo-electron microscopy to identify strain-specific patterns of amyloid-β intracellular formation and propagation, determine the biochemical manifestation of variants and their impact in organoids, and delineate molecular signatures associated with variants. A $667,706 subaward to the Georgia Institute of Technology Research Corporation will support the organoid modeling aspects of understanding functional impacts. The funding advances the goals of the Aging Research program through further elucidating the pathogenic properties and targets for therapeutic intervention in Alzheimer's disease.

Generated 1/6/24, 7:01 PM