This $1,623,119 project grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research characterizing Alzheimer's amyloid-beta oligomer structures through May 2025. The grantee, Georgia Tech Research Corporation, will use solid-state nuclear magnetic resonance and cryo-electron microscopy to achieve high-resolution structural characterization of a unique 150 kDa amyloid-beta oligomer. Researchers will obtain a three-dimensional image of the oligomer using cryo-EM and measure complementary atomic constraints with solid-state NMR. They will also test hypothesized assembly pathways inspired by the 150 kDa oligomer structure to produce new oligomers compatible with the experimental workflows. Two subawards totaling $244,000 will support related computational modeling at the University of Illinois and biochemical procedures including oligomer preparation and analysis at Mayo Clinic Jacksonville. Outcomes aim to advance understanding of which amyloid-beta oligomer structures should be targeted by Alzheimer's therapies.
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