This $619,681 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to The Leland Stanford Junior University (Stanford University) will develop innovative research tools and generate multi-omics datasets to study the complex genetic interactions underlying the pathogenesis of Alzheimer's disease (AD). The key products and services to be delivered include:
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Combo-seq/tag, a toolkit that combines precise installation of multiple AD risk alleles (Combo-seq) with a multiplex protein tagging tool (Combo-tag) for studying endogenous protein interactions in human stem cell models.
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Generation of a Combo-seq/tag mouse strain compatible with the 5XFAD AD model for in vivo studies.
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Multi-omics datasets derived from the Combo-seq/tag system to provide insights into the mechanistic links between aging and neurodegeneration, potentially revealing new targets for AD diagnosis and therapy.
The project will run from March 2025 to January 2030, leveraging Stanford University's expertise in stem cell biology, genetics, and animal models to advance the understanding of late-onset AD pathogenesis.
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